Arterial stiffness is a growing epidemic associated with increased risk of cardiovascular
events, dementia, and death. Decreased compliance of the central vasculature alters arterial …

Physical stiffening of the large arteries is the central paradigm of vascular aging. Indeed,
stiffening in the larger central arterial system, such as the aortic tree, significantly contributes …

Nitric oxide (NO) is synthesized by at least three distinct isoforms of NO synthase (NOS).
Their substrate and cofactor requirements are very similar. All three isoforms have some …

Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three
distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and …

Hypertension is a major risk factor for cardiovascular disease, and reduction of elevated
blood pressure significantly reduces the risk of cardiovascular events. Endothelial …

associated with endothelial dysfunction, cannot fully account for the advanced state of
arterial stiffening and the high rate of cardiovascular morbidity and mortality. 23 However …

This review examines the association of a subset of endothelial nitric oxide synthase gene
(NOS3) polymorphisms (Glu298Asp, intron 4, and-786T> C) with cardiovascular disease …

Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been associated
inconsistently with cardiovascular diseases. A maldistribution of eNOS variants among …

Objective To investigate functional differences between the various genotypes with respect
to basal nitric oxide (NO) production, we estimated the response to endothelial NO synthase …

Genes contribute significantly to interpopulation differences in vascular disease. Endothelial
nitric oxide synthase (eNOS)—a key regulator of vascular nitric oxide production—has been …