Microbial and animal rhodopsins: structures, functions, and molecular mechanisms
Organisms of all domains of life use photoreceptor proteins to sense and respond to light.
The light-sensitivity of photoreceptor proteins arises from bound chromophores such as …
The light-sensitivity of photoreceptor proteins arises from bound chromophores such as …
[HTML][HTML] Rhodopsin, light-sensor of vision
KP Hofmann, TD Lamb - Progress in Retinal and Eye Research, 2023 - Elsevier
The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …
Crystal structure of a human GABAA receptor
Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid
inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers …
inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers …
Structural basis of Smoothened regulation by its extracellular domains
Developmental signals of the Hedgehog (Hh) and Wnt families are transduced across the
membrane by Frizzled-class G-protein-coupled receptors (GPCRs) composed of both a …
membrane by Frizzled-class G-protein-coupled receptors (GPCRs) composed of both a …
The scanning model for translation: an update.
M Kozak - The Journal of cell biology, 1989 - rupress.org
The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-
end of messenger RNA and then migrate, stop** at the first AUG codon in a favorable …
end of messenger RNA and then migrate, stop** at the first AUG codon in a favorable …
G protein–coupled receptor rhodopsin
K Palczewski - Annu. Rev. Biochem., 2006 - annualreviews.org
The rhodopsin crystal structure provides a structural basis for understanding the function of
this and other G protein–coupled receptors (GPCRs). The major structural motifs observed …
this and other G protein–coupled receptors (GPCRs). The major structural motifs observed …
Structure and function in rhodopsin: High-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N …
An HEK293S cell line resistant to ricin was prepared by mutagenesis by using ethyl
methanesulfonate. It was shown to lack N-acetylglucosaminyltransferase I (GnTI) activity …
methanesulfonate. It was shown to lack N-acetylglucosaminyltransferase I (GnTI) activity …
Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
Conformational changes are thought to underlie the activation of heterotrimeric GTP-binding
protein (G protein)—coupled receptors. Such changes in rhodopsin were explored by …
protein (G protein)—coupled receptors. Such changes in rhodopsin were explored by …
Mechanisms of inhibition and activation of extrasynaptic αβ GABAA receptors
Type A GABA (γ-aminobutyric acid) receptors represent a diverse population in the
mammalian brain, forming pentamers from combinations of α-, β-, γ-, δ-, ε-, ρ-, θ-and π …
mammalian brain, forming pentamers from combinations of α-, β-, γ-, δ-, ε-, ρ-, θ-and π …
Structural basis for GABAA receptor potentiation by neurosteroids
Type A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of inhibitory
neurotransmission in the human brain. Endogenous neurosteroids interact with GABAARs to …
neurotransmission in the human brain. Endogenous neurosteroids interact with GABAARs to …