Biology and evolution of bacterial toxin–antitoxin systems
Toxin–antitoxin systems are widespread in bacterial genomes. They are usually composed
of two elements: a toxin that inhibits an essential cellular process and an antitoxin that …
of two elements: a toxin that inhibits an essential cellular process and an antitoxin that …
Type II toxin-antitoxin systems: evolution and revolutions
Type II toxin-antitoxin (TA) systems are small genetic elements composed of a toxic protein
and its cognate antitoxin protein, the latter counteracting the toxicity of the former. While TA …
and its cognate antitoxin protein, the latter counteracting the toxicity of the former. While TA …
Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution
HR Ramage, LE Connolly, JS Cox - PLoS genetics, 2009 - journals.plos.org
Toxin-antitoxin (TA) systems, stress-responsive genetic elements ubiquitous in microbial
genomes, are unusually abundant in the major human pathogen Mycobacterium …
genomes, are unusually abundant in the major human pathogen Mycobacterium …
Bacterial toxin–antitoxin systems: more than selfish entities?
L Van Melderen, M Saavedra De Bast - PLoS genetics, 2009 - journals.plos.org
Bacterial toxin–antitoxin (TA) systems are diverse and widespread in the prokaryotic
kingdom. They are composed of closely linked genes encoding a stable toxin that can harm …
kingdom. They are composed of closely linked genes encoding a stable toxin that can harm …
Diversity of bacterial type II toxin–antitoxin systems: a comprehensive search and functional analysis of novel families
R Leplae, D Geeraerts, R Hallez… - Nucleic acids …, 2011 - academic.oup.com
Type II toxin–antitoxin (TA) systems are generally composed of two genes organized in an
operon, encoding a labile antitoxin and a stable toxin. They were first discovered on …
operon, encoding a labile antitoxin and a stable toxin. They were first discovered on …
Toxin–antitoxin systems: why so many, what for?
L Van Melderen - Current opinion in microbiology, 2010 - Elsevier
Toxin–antitoxin (TA) systems are small genetic modules that are abundant in bacterial
genomes. Three types have been described so far, depending on the nature and mode of …
genomes. Three types have been described so far, depending on the nature and mode of …
[HTML][HTML] Toxin-antitoxin systems as multilevel interaction systems
N Goeders, L Van Melderen - Toxins, 2014 - mdpi.com
Toxin-antitoxin (TA) systems are small genetic modules usually composed of a toxin and an
antitoxin counteracting the activity of the toxic protein. These systems are widely spread in …
antitoxin counteracting the activity of the toxic protein. These systems are widely spread in …
Toxins-antitoxins: diversity, evolution and function
F Hayes, L Van Melderen - Critical reviews in biochemistry and …, 2011 - Taylor & Francis
Genes for toxin-antitoxin (TA) complexes are widespread in prokaryote genomes, and
species frequently possess tens of plasmid and chromosomal TA loci. The complexes are …
species frequently possess tens of plasmid and chromosomal TA loci. The complexes are …
Kee** the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to
bacterial plasmids where they function to mediate the maintenance and stability of usually …
bacterial plasmids where they function to mediate the maintenance and stability of usually …
Bacterial toxin-antitoxin systems: Translation inhibitors everywhere
Toxin-antitoxin (TA) systems are composed of two elements: a toxic protein and an antitoxin
which is either an RNA (type I and III) or a protein (type II). Type II systems are abundant in …
which is either an RNA (type I and III) or a protein (type II). Type II systems are abundant in …