Phenomenology of the initial burst release of drugs from PLGA microparticles
Poly (lactic-co-glycolic acid)(PLGA) is the most prevalent polymer drug delivery vehicle in
use today. There are about 20 commercialized drug products in which PLGA is used as an …
use today. There are about 20 commercialized drug products in which PLGA is used as an …
Nucleic acid and oligonucleotide delivery for activating innate immunity in cancer immunotherapy
A group of nucleic acids and oligonucleotides play various roles in the innate immune
system. They can stimulate pattern recognition receptors to activate innate immune cells …
system. They can stimulate pattern recognition receptors to activate innate immune cells …
Top-down fabricated microplates for prolonged, intra-articular matrix metalloproteinase 13 siRNA nanocarrier delivery to reduce post-traumatic osteoarthritis
Post-traumatic osteoarthritis (PTOA) associated with joint injury triggers a degenerative cycle
of matrix destruction and inflammatory signaling, leading to pain and loss of function. Here …
of matrix destruction and inflammatory signaling, leading to pain and loss of function. Here …
Metal-organic framework for biomimetic nitric oxide generation and anticancer drug delivery
The potential therapeutic implications of nitric oxide (NO) have drawn a great deal of interest
for reversing multidrug resistance (MDR) in cancer; however, previous strategies utilized …
for reversing multidrug resistance (MDR) in cancer; however, previous strategies utilized …
Structural optimization of polymeric carriers to enhance the immunostimulatory activity of molecularly defined RIG-I agonists
ME Jacobson, KW Becker, CR Palmer… - ACS Central …, 2020 - ACS Publications
RNA ligands of retinoic acid-inducible gene I (RIG-I) hold significant promise as antiviral
agents, vaccine adjuvants, and cancer immunotherapeutics, but their efficacy is hindered by …
agents, vaccine adjuvants, and cancer immunotherapeutics, but their efficacy is hindered by …
Reduced administration frequency for the treatment of fungal keratitis: a sustained natamycin release from a micellar solution
Background Natamycin is the only topical ophthalmic antifungal drug approved by the Food
and Drug Administration (FDA) of the United States, but has unsatisfactory factors such as …
and Drug Administration (FDA) of the United States, but has unsatisfactory factors such as …
Pharmacological activation of cGAS for cancer immunotherapy
KM Garland, JC Rosch, CS Carson… - Frontiers in …, 2021 - frontiersin.org
When compartmentally mislocalized within cells, nucleic acids can be exceptionally
immunostimulatory and can even trigger the immune-mediated elimination of cancer …
immunostimulatory and can even trigger the immune-mediated elimination of cancer …
Nanoparticle delivery of immunostimulatory Alu RNA for cancer immunotherapy
It was recently found that patients with relapsing remitting multiple sclerosis exhibit
widespread loss of adenosine-to-inosine (A-to-I) RNA editing, which contributes to the …
widespread loss of adenosine-to-inosine (A-to-I) RNA editing, which contributes to the …
Inhalable polymeric microparticles as pharmaceutical porous powder for drug administration
In this work, the production of inhalable polymeric microparticles with modulable porosity is
described. The starting polymeric material was the PHEA-g-RhB-g-PLA graft copolymer …
described. The starting polymeric material was the PHEA-g-RhB-g-PLA graft copolymer …
Structural Optimization of Antioxidant Copolymers for Drug Delivery Applications
CR DeJulius - 2024 - search.proquest.com
Oxidative stress, the pathological elevation of reactive oxygen species (ROS), participates in
the propagation of many diseases, including osteoarthritis and optic neuropathies. Polymers …
the propagation of many diseases, including osteoarthritis and optic neuropathies. Polymers …