The HDM allergen orchestra and its cysteine protease maestro: Stimulators of kaleidoscopic innate immune responses

A Jacquet - Molecular Immunology, 2023 - Elsevier
House dust mite (HDM) encloses an explosive cocktail of allergenic proteins sensitizing
hundreds of millions of people worldwide. To date, the innate cellular and molecular …

Inhalant mammal-derived lipocalin allergens and the innate immunity

T Virtanen - Frontiers in Allergy, 2022 - frontiersin.org
A major part of important mammalian respiratory allergens belongs to the lipocalin family of
proteins. By this time, 19 respiratory mammalian lipocalin allergens have been registered in …

Immunoproteasome inhibition reduces the T helper 2 response in mouse models of allergic airway inflammation

F Oliveri, M Basler, TN Rao, HJ Fehling… - Frontiers in …, 2022 - frontiersin.org
Background Allergic asthma is a chronic disease and medical treatment often fails to fully
control the disease in the long term, leading to a great need for new therapeutic approaches …

New approaches to immunotherapy in house dust mite allergy

IS Kim - Clinical and Experimental Pediatrics, 2022 - pmc.ncbi.nlm.nih.gov
Allergen immunotherapy (AIT) has developed over the last few decades and has emerged
as a promising treatment. House dust mite (HDM) is a target allergen in AIT, and various …

The genome‐wide response of Dermatophagoides pteronyssinus to cystatin A, a peptidase inhibitor from human skin, sheds light on its digestive physiology and …

JC Vidal‐Quist, F Ortego, S Rombauts… - Insect Molecular …, 2024 - Wiley Online Library
The digestive physiology of house dust mites (HDMs) is particularly relevant for their
allergenicity since many of their allergens participate in digestion and are excreted into …

Anti-inflammatory effects of neuregulin-1 in HaCaT keratinocytes and atopic dermatitis-like mice stimulated with Der p 38

JH Yun, Y Hong, MH Hong, G Kim, JS Lee, RS Woo… - Cytokine, 2024 - Elsevier
Abstract Neuregulin (NRG)-1 plays fundamental roles in several organ systems after binding
to its receptors, ErbB2 and ErbB4. This study examines the role of NRG-1 in atopic dermatitis …

Neuregulin-1 suppresses anti-apoptotic effect of Der p 38 on neutrophils by inhibition of cytokine secretion

Y Hong, JH Choi, MH Hong, G Kim, JS Lee… - Molecular & Cellular …, 2023 - Springer
Background Neuregulin (NRG) plays essential roles in the growth and differentiation of
epithelial, neuronal and glial cells. Asthma is a chronic respiratory disease characterized by …

Anti-inflammatory effects of neuregulin-1 via the downregulation of IL-6, IL-8, and MCP-1 secretion

JS Lee - Biomedical Science Letters, 2022 - koreascience.kr
The trophic factor Neuregulin-1 (NRG-1) plays a critical role in the development of the
peripheral nervous system and the repair of nerve injuries. The regulation of neutrophil …

The Inhibitory Effects of KRGE on Mixed Granulocytic Asthma due to Der p 38

IS KIM - The Korean Journal of Food & Health Convergence, 2024 - koreascience.kr
Asthma is a chronic inflammatory airway disease triggered by allergens including house
dust mite, food and environmental factors. Korean red ginseng extract (KRGE) has anti …

Differential Asthmatic Effect Due to House Dust Mite Depending on Age and Exposure Duration

JS Lee - Biomedical Science Letters, 2024 - koreascience.kr
Asthma is a chronic lung disease characterized by wheezing, cough, and chest pain. The
objective of this study was to examine asthmatic effect due to house dust mite (HDM) …