Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair
Bone tissue has a remarkable ability to regenerate and heal itself. However, large bone
defects and complex fractures still present a significant challenge to the medical community …
defects and complex fractures still present a significant challenge to the medical community …
Mesenchymal stromal cells: biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation
CM Kolf, E Cho, RS Tuan - Arthritis research & therapy, 2007 - Springer
Recent advances in understanding the cellular and molecular signaling pathways and
global transcriptional regulators of adult mesenchymal stem cells have provided new …
global transcriptional regulators of adult mesenchymal stem cells have provided new …
Materials roles for promoting angiogenesis in tissue regeneration
Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …
tissue-engineered constructs. Although many biochemical signaling molecules have been …
Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration
DHR Kempen, L Lu, A Hei**k, TE Hefferan… - Biomaterials, 2009 - Elsevier
Bone regeneration is a coordinated cascade of events regulated by several cytokines and
growth factors. Angiogenic growth factors are predominantly expressed during the early …
growth factors. Angiogenic growth factors are predominantly expressed during the early …
Angiogenesis in tissue engineering: breathing life into constructed tissue substitutes
MW Laschke, Y Harder, M Amon, I Martin… - Tissue …, 2006 - liebertpub.com
Long-term function of three-dimensional (3D) tissue constructs depends on adequate
vascularization after implantation. Accordingly, research in tissue engineering has focused …
vascularization after implantation. Accordingly, research in tissue engineering has focused …
Uncertainty in the niches that maintain haematopoietic stem cells
MJ Kiel, SJ Morrison - Nature Reviews Immunology, 2008 - nature.com
Haematopoietic stem cell (HSC) niches are specialized microenvironments that contain
stem cells and regulate their maintenance. Cells at the interface of bone and the bone …
stem cells and regulate their maintenance. Cells at the interface of bone and the bone …
Bone marrow–derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature
Vascular tissue engineering requires a ready source of endothelial cells and perivascular
cells. Here, we evaluated human bone marrow–derived mesenchymal stem cells (hMSCs) …
cells. Here, we evaluated human bone marrow–derived mesenchymal stem cells (hMSCs) …
Engineering robust and functional vascular networks in vivo with human adult and cord blood–derived progenitor cells
The success of therapeutic vascularization and tissue engineering will rely on our ability to
create vascular networks using human cells that can be obtained readily, can be expanded …
create vascular networks using human cells that can be obtained readily, can be expanded …
Advanced gelatin-based vascularization bioinks for extrusion-based bioprinting of vascularized bone equivalents
Bone tissue is highly vascularized. The crosstalk of vascular and osteogenic cells is not only
responsible for the formation of the strongly divergent tissue types but also for their …
responsible for the formation of the strongly divergent tissue types but also for their …
Vascularized bone tissue engineering: approaches for potential improvement
Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …
However, classical bone TE strategies have been hampered mainly due to the lack of …