While behavioral interventions remain the mainstay of treatment of autism spectrum disorder
(ASD), several potential targeted treatments addressing the underlying neurophysiology of …

The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …

The hippocampus is one of the brain areas affected by autism spectrum disorder (ASD).
Individuals with ASD typically have impairments in hippocampus-dependent learning …

Anxiety disorders are increasingly prevalent, affect people's ability to do things, and
decrease quality of life. Due to lack of objective tests, they are underdiagnosed and sub …

Excessive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu
1/5) is a core pathophysiology of fragile X syndrome (FX); however, the differentially …

Understanding the complexities of the human brain and its associated disorders poses a
significant challenge in neuroscience. Traditional research methods have limitations in …

Fragile X syndrome (FXS) is the most common form of monogenic hereditary cognitive
impairment. FXS patient exhibit a high comorbidity rate with autism spectrum disorders …

The fragile X-related disorders are an important group of hereditary disorders that are
caused by expanded CGG repeats in the 5′ untranslated region of the FMR1 gene or by …

Fragile X syndrome is caused by FMR1 gene silencing and loss of the encoded fragile X
mental retardation protein (FMRP), which binds to mRNA and regulates translation. Studies …

In fragile X syndrome (FX), the leading monogenic cause of autism, excessive neuronal
protein synthesis is a core pathophysiology; however, an overall increase in protein …