Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …

Mathematical modelling of the macroscopic electrical activity of the brain is highly nontrivial
and requires a detailed understanding of not only the associated mathematical techniques …

Interictal epileptiform discharges (IEDs), also known as interictal spikes, are large
intermittent electrophysiological events observed between seizures in patients with epilepsy …

We developed a neural network model that can account for major elements common to
human focal seizures. These include the tonic-clonic transition, slow advance of clinical …

Focal seizure propagation is classically thought to be spatially contiguous. However,
distribution of seizures through a large-scale epileptic network has been theorized. Here, we …

The cellular activity underlying human focal seizures, and its relationship to key signatures
in the EEG recordings used for therapeutic purposes, has not been well characterized …

Our understanding of the genetic aetiology of paediatric epilepsies has grown substantially
over the last decade. However, in order to translate improved diagnostics to personalised …

Objective Stereotactic laser amygdalohippocampotomy (SLAH) is an appealing option for
patients with temporal lobe epilepsy, who often require intracranial monitoring to confirm …

The concept of an epileptic network is based on the longstanding clinical observation that
ictal electroencephalography (EEG) patterns cannot be easily explained by the traditional …

During human seizures, organized waves of voltage activity rapidly sweep across the cortex.
Two contradictory theories describe the source of these fast traveling waves: either a slowly …