Cancer and diabetes are amongst the leading causes of deaths worldwide. There is an
alarming rise in cancer incidences and mortality, with approximately 18.1 million new cases …

Cellular DNA is constantly chemically altered by exogenous and endogenous agents. As all
processes of life depend on the transmission of the genetic information, multiple biological …

Alkylating agents are genotoxic chemicals that can induce and treat various types of cancer.
This occurs through covalent bonding with cellular macromolecules, in particular DNA …

Nitrosamines occur widespread in food, drinking water, cosmetics, as well as tobacco smoke
and can arise endogenously. More recently, nitrosamines have been detected as impurities …

Colorectal cancer (CRC) is one of the major tumor entities worldwide, with an increasing
incidence in younger people. CRC formation is causally linked to various genetic, life-style …

A genotoxic carcinogen, N‐nitrosodimethylamine (NDMA), was detected as a synthesis
impurity in some valsartan drugs in 2018, and other N‐nitrosamines, such as N …

The metabolic plasticity of mitochondria ensures cell development, differentiation, and
survival. The peptidase OMA1 regulates mitochondrial morphology via OPA1 and stress …

The endogenous disulfide α-lipoic acid (LA) is an essential mitochondrial co-factor. In
addition, LA and its reduced counterpart dihydro lipoic acid form a potent redox couple with …

Colorectal cancer (CRC) is one of the most common tumor entities, which is causally linked
to DNA repair defects and inflammatory bowel disease (IBD). Here, we studied the role of …

Heme oxygenase-1 (HO-1) is an enzyme located at the endoplasmic reticulum, which is
responsible for the degradation of cellular heme into ferrous iron, carbon monoxide and …