Pathophysiology of COVID-19-associated acute kidney injury

M Legrand, S Bell, L Forni, M Joannidis… - Nature Reviews …, 2021 - nature.com
Although respiratory failure and hypoxaemia are the main manifestations of COVID-19,
kidney involvement is also common. Available evidence supports a number of potential …

SARS-CoV-2: from its discovery to genome structure, transcription, and replication

AC Brant, W Tian, V Majerciak, W Yang, ZM Zheng - Cell & bioscience, 2021 - Springer
SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia
COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single …

Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models

AA Cohen, N van Doremalen, AJ Greaney, H Andersen… - Science, 2022 - science.org
To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …

ACE2: the major cell entry receptor for SARS-CoV-2

F Scialo, A Daniele, F Amato, L Pastore, MG Matera… - Lung, 2020 - Springer
Despite the unprecedented effort of the scientific community, the novel SARS-CoV-2 virus
has infected more than 46 million people worldwide, killing over one million two hundred …

Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis

G Corona, A Pizzocaro, W Vena, G Rastrelli… - Reviews in Endocrine …, 2021 - Springer
The presence of SARS-CoV-2 was officially documented in Europe at the end of February
2020. Despite many observations, the real impact of COVID-19 in the European Union (EU) …

Depression pandemic and cardiovascular risk in the COVID-19 era and long COVID syndrome: Gender makes a difference

V Bucciarelli, M Nasi, F Bianco, J Seferovic… - Trends in cardiovascular …, 2022 - Elsevier
The ongoing COVID-19 pandemic highlighted a significant interplay between cardiovascular
disease (CVD), COVID-19 related inflammatory status, and depression. Cardiovascular (CV) …

A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection

DA Jamison Jr, S Anand Narayanan… - European Journal of …, 2022 - nature.com
COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives
and 257 million cases reported globally. This virus and disease have significantly affected …

Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

YW Zhou, Y **e, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …

Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention

E Shirbhate, J Pandey, VK Patel, M Kamal… - Pharmacological …, 2021 - Springer
Angiotensin-converting enzyme (ACE) and its homologue, ACE2, are commonly allied with
hypertension, renin–angiotensin–aldosterone system pathway, and other cardiovascular …

SARS-CoV-2 spike protein induces degradation of junctional proteins that maintain endothelial barrier integrity

S Raghavan, DB Kenchappa, MD Leo - Frontiers in cardiovascular …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the Angiotensin
converting enzyme 2 (ACE2) receptor present on the cell surface to enter cells. Angiotensin …