The correct folding is a key process for a protein to acquire its functional structure and
conformation. Prefoldin is a well-known chaperone protein that regulates the correct folding …

Abstract The R2TP/Prefoldin-like (R2TP/PFDL) complex has emerged as a cochaperone
complex involved in the assembly of a number of critical protein complexes including …

Prefoldins (PFDNs) are evolutionary conserved co-chaperones, initially discovered in
archaea but universally present in eukaryotes. PFDNs are prevalently organized into hetero …

The tripartite interaction between the chromatin remodeler complex RSC, RNA polymerase
subunit Rpb5 and prefoldin-like Bud27 is necessary for proper RNA pol II elongation. Indeed …

The unconventional prefoldin URI/RMP, in humans, and its orthologue in yeast, Bud27, have
been proposed to participate in the biogenesis of the RNA polymerases. However, this role …

Unconventional prefoldin RPB5 Interactor (URI) was identified as a transcriptional repressor
that binds RNA polymerase II (pol II) through interaction with the RPB5/POLR2E subunit …

Despite decades of effort to develop effective therapy and to identify promising new drugs,
prostate cancer is lethal once it progresses to castration-resistant disease. Studies show mis …

Bud27 is a prefoldin-like protein that participates in transcriptional regulation mediated by
the three RNA polymerases in Saccharomyces cerevisiae. Lack of Bud27 significantly …

URI (unconventional prefoldin RPB5 interactor protein) is an unconventional prefoldin, RNA
polymerase II interactor that functions as a transcriptional repressor and is part of a larger …

Understanding the functional connection that occurs for the three nuclear RNA polymerases
to synthesize ribosome components during the ribosome biogenesis process has been the …