Inflammatory bowel disease (IBD) is a complex multifactorial chronic inflammatory disease,
that includes Crohn's disease (CD) and ulcerative colitis (UC), having progressively …

Intestinal barriers play a crucial role in human physiology, both in homeostatic and
pathological conditions. Disruption of the intestinal barrier is a significant factor in the …

Antibiotic use is a risk factor for development of inflammatory bowel diseases (IBDs). IBDs
are characterized by a damaged mucus layer, which does not separate the intestinal …

Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and
underlies the leading causes of morbidity and mortality, both within the United States and …

Abstract Background Sec23 homolog A (SEC23A), a core component of coat protein
complex II (COPII), has been reported to be involved in several cancers. However, the role of …

The gut microbiota plays a key role in host health and disease, particularly through their
interactions with the immune system. Intestinal homeostasis is dependent on the symbiotic …

A complex mucus network made up of large polymers of the mucin-family glycoprotein
MUC2 exists between the large intestinal microbial mass and epithelial and immune cells …

Background: Ulcerative colitis (UC) is an intestinal inflammatory disease that is strongly
associated with mitochondrial damage and dysfunction as well as mitophagy and lacks of …

Recent evidence indicates that repeated antibiotic usage lowers microbial diversity and
ultimately changes the gut microbiota community. However, the physiological effects of …

Colitis-associated colon cancer (CAC) is a distinct form of colorectal cancer that emerges
from prolonged colitis in individuals with inflammatory bowel disease (IBD). Chronic …