Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …

Over the past decade, it has become clear that mammalian genomes encode thousands of
long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological …

Here, we present Perturb-ATAC, a method that combines multiplexed CRISPR interference
or knockout with genome-wide chromatin accessibility profiling in single cells based on the …

Cell-type-and condition-specific profiles of gene expression require coordination between
protein-coding gene promoters and cis-regulatory sequences called enhancers. Enhancers …

Mammalian genomes are extensively transcribed, which produces a large number of both
coding and non-coding transcripts. Various RNAs are physically associated with chromatin …

ABSTRACT Cyclin-dependent kinase 9 (CDK9) is critical for RNA Polymerase II (Pol II)
transcription initiation, elongation, and termination in several key biological processes …

Precise gene expression ensures proper stem and progenitor cell differentiation, lineage
commitment and organogenesis during mammalian development. ATP-dependent …

Summary 7SK is a conserved noncoding RNA that regulates transcription by sequestering
the transcription factor P-TEFb. 7SK function entails complex changes in RNA structure, but …

Targeting bromodomains (BRDs) of the bromo-and-extra-terminal (BET) family offers
opportunities for therapeutic intervention in cancer and other diseases. Here, we profile the …