Race, ancestry, and genes: implications for defining disease risk

RA Kittles, KM Weiss - Annual review of genomics and human …, 2003 - annualreviews.org
Geneticists are interested in finding genes associated with disease. Because of widespread
health disparities, race is a variable that is often said to be relevant in this context. The idea …

The relevance of bioinformatics applications in the discovery of vaccine candidates and potential drugs for COVID-19 treatment

OS Chukwudozie, VC Duru… - … and Biology Insights, 2021 - journals.sagepub.com
The application of bioinformatics to vaccine research and drug discovery has never been so
essential in the fight against infectious diseases. The greatest combat of the 21st century …

Common and well‐documented HLA alleles: 2012 update to the CWD catalogue

SJ Mack, P Cano, JA Hollenbach, J He… - Tissue …, 2013 - Wiley Online Library
We have updated the catalogue of common and well‐documented (CWD) human leukocyte
antigen (HLA) alleles to reflect current understanding of the prevalence of specific allele …

Common and well-documented HLA alleles: report of the Ad-Hoc committee of the american society for histocompatiblity and immunogenetics

P Cano, W Klitz, SJ Mack, M Maiers, SGE Marsh… - Human immunology, 2007 - Elsevier
In histocompatibility testing some genotype ambiguities are almost always resolved into the
genotype with the most common alleles. To achieve unambiguous assignments additional …

HLA DNA sequence variation among human populations: molecular signatures of demographic and selective events

S Buhler, A Sanchez-Mazas - PloS one, 2011 - journals.plos.org
Molecular differences between HLA alleles vary up to 57 nucleotides within the peptide
binding coding region of human Major Histocompatibility Complex (MHC) genes, but it is still …

Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci

K Cao, AM Moormann, KE Lyke, C Masaberg… - Tissue …, 2004 - Wiley Online Library
The allelic and haplotypic diversity of the HLA‐A, HLA‐B, and HLA‐C loci was investigated
in 852 subjects from five sub‐Saharan populations from Kenya (Nandi and Luo), Mali …

Variation of female and male lineages in sub-Saharan populations: the importance of sociocultural factors

G Destro-Bisol, F Donati, V Coia, I Boschi… - Molecular biology …, 2004 - academic.oup.com
In this paper, we present a study of genetic variation in sub-Saharan Africa, which is based
on published and unpublished data on fast-evolving (hypervariable region 1 of …

Inheritable variable sizes of DNA stretches in the human MHC: conserved extended haplotypes and their fragments or blocks

EJ Yunis, CE Larsen, M Fernandez‐Viña… - Tissue …, 2003 - Wiley Online Library
The difference in sizes of conserved stretches of DNA sequence within the major
histocompatibility complex (MHC) in human individuals constitutes an underappreciated …

Immunogenetics as a tool in anthropological studies

A Sanchez‐Mazas, M Fernandez‐Viña… - …, 2011 - Wiley Online Library
The genes coding for the main molecules involved in the human immune system–
immunoglobulins, human leucocyte antigen (HLA) molecules and killer‐cell immunoglobulin …

Working toward a synthesis of archaeological, linguistic, and genetic data for inferring African population history

LB Scheinfeldt, S Soi, SA Tishkoff - … of the National Academy of Sciences, 2010 - pnas.org
Although Africa is the origin of modern humans, the pattern and distribution of genetic
variation and correlations with cultural and linguistic diversity in Africa have been …