Wnt/β-catenin signaling is an evolutionarily conserved and versatile pathway that is known
to be involved in embryonic development, tissue homeostasis and a wide variety of human …

At the heart of the canonical Wnt signaling pathway is the β-catenin destruction complex,
which functions in the absence of Wnt signaling to keep the cytosolic and nuclear levels of β …

Degradation of cytosolic β-catenin by the APC/Axin1 destruction complex represents the key
regulated step of the Wnt pathway. It is incompletely understood how the Axin1 complex …

Glycogen synthase kinase 3 (GSK3), a constitutively acting multi‐functional serine threonine
kinase is involved in diverse physiological pathways ranging from metabolism, cell cycle …

Axon growth is a highly regulated process that requires stimulating signals from extracellular
factors. The extracellular signals are then transduced to regulate coordinately gene …

Epithelial cells usually exist as sheets of immotile, tightly packed, well-coupled, polarized
cells with distinct apical, basal and lateral surfaces. Remarkably, these cells can …

ABSTRACT N-myc downstream-regulated gene 1 (NDRG1) is a potent metastasis
suppressor that has been demonstrated to inhibit the transforming growth factor β (TGF-β) …

The Wnt/β‐catenin signaling pathway is critical in both cellular proliferation and organismal
development. However, how the β‐catenin degradation complex is inhibited upon Wnt …

The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are
involved in developmental, metabolic, and tumorigenic processes. Maf proteins are …

Phosphorylation of eukaryotic initiation factor 2α (eIF2α) is mediated by a family of kinases
that respond to various forms of environmental stress. The eIF2α kinases are critical for …