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Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis
The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …
Mechanisms of bone development and repair
Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …
formation of the body scaffold. The repair potential of bone and its surrounding …
[PDF][PDF] Role and regulation of RUNX2 in osteogenesis
Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …
Building strong bones: molecular regulation of the osteoblast lineage
The past 15 years have witnessed tremendous progress in the molecular understanding of
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …
Development of the endochondral skeleton
Much of the mammalian skeleton is composed of bones that originate from cartilage
templates through endochondral ossification. Elucidating the mechanisms that control …
templates through endochondral ossification. Elucidating the mechanisms that control …
[HTML][HTML] Reaching a genetic and molecular understanding of skeletal development
In the last ten years, we have made considerable progress in our genetic and molecular
understanding of all aspects of skeletal development, chondrogenesis, joint formation, and …
understanding of all aspects of skeletal development, chondrogenesis, joint formation, and …
All for one and one for all: condensations and the initiation of skeletal development
Condensation is the pivotal stage in the development of skeletal and other mesenchymal
tissues. It occurs when a previously dispersed population of cells gathers together to …
tissues. It occurs when a previously dispersed population of cells gathers together to …
The osteoblast: a sophisticated fibroblast under central surveillance
The study of the biology of osteoblasts, or bone-forming cells, illustrates how mammalian
genetics has profoundly modified our understanding of cell differentiation and physiologic …
genetics has profoundly modified our understanding of cell differentiation and physiologic …
Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation
In vertebrate hearts, the ventricular trabecular myocardium develops as a sponge-like
network of cardiomyocytes that is critical for contraction and conduction, ventricular …
network of cardiomyocytes that is critical for contraction and conduction, ventricular …
Signaling and transcriptional regulation in osteoblast commitment and differentiation
The major event that triggers osteogenesis is the transition of mesenchymal stem cells into
bone forming, differentiating osteoblast cells. Osteoblast differentiation is the primary …
bone forming, differentiating osteoblast cells. Osteoblast differentiation is the primary …