Since an immunoreceptor tyrosine‐based inhibition motif (ITIM) was first identified in the
intracytoplasmic domain of FcγRIIB, ITIMs have been found in a large number of inhibitory …

Over the past 10 years our knowledge of cellular and molecular dynamics of teleost humoral
immunity has increased enormously to now include: the existence of multiple isotypes …

Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …

Background In mammals, the members of the tripartite motif (TRIM) protein family are
involved in various cellular processes including innate immunity against viral infection …

Tripartite motif proteins (TRIM) constitute a large family of proteins containing a RING-Bbox-
Coiled Coil motif followed by different C-terminal domains. Involved in ubiquitination, TRIM …

MHC class I (MHC-I) polymorphisms are associated with the outcome of some viral
infections and autoimmune diseases. MHC-I proteins present antigenic peptides and are …

Natural killer (NK) cells affect a form of innate immunity that recognizes and eliminates cells
that are infected with certain viruses or have undergone malignant transformation. In …

Leukocyte immune-type receptors (LITRs) are a large family of teleost immunoregulatory
receptor-types belonging to the immunoglobulin superfamily. These immune genes are …

Akin to their mammalian counterparts, teleost fish possess a complex assortment of highly
specialized immune cells that are capable of unleashing potent innate immune responses to …

Host immunity is classically divided into “innate” and “adaptive.” While the former has always
been regarded as the first, rapid, and antigen-nonspecific reaction to invading pathogens …