Emerging concepts in liquid biopsies
S Perakis, MR Speicher - BMC medicine, 2017 - Springer
Characterizing and monitoring tumor genomes with blood samples could achieve significant
improvements in precision medicine. As tumors shed parts of themselves into the circulation …
improvements in precision medicine. As tumors shed parts of themselves into the circulation …
The potential of liquid biopsies for the early detection of cancer
Precision medicine refers to the choosing of targeted therapies based on genetic data. Due
to the increasing availability of data from large-scale tumor genome sequencing projects …
to the increasing availability of data from large-scale tumor genome sequencing projects …
Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death
The level of copy number alteration (CNA), termed CNA burden, in the tumor genome is
associated with recurrence of primary prostate cancer. Whether CNA burden is associated …
associated with recurrence of primary prostate cancer. Whether CNA burden is associated …
Inferring expressed genes by whole-genome sequencing of plasma DNA
The analysis of cell-free DNA (cfDNA) in plasma represents a rapidly advancing field in
medicine. cfDNA consists predominantly of nucleosome-protected DNA shed into the …
medicine. cfDNA consists predominantly of nucleosome-protected DNA shed into the …
Expandable and reversible copy number amplification drives rapid adaptation to antifungal drugs
Previously, we identified long repeat sequences that are frequently associated with genome
rearrangements, including copy number variation (CNV), in many diverse isolates of the …
rearrangements, including copy number variation (CNV), in many diverse isolates of the …
Preferred end coordinates and somatic variants as signatures of circulating tumor DNA associated with hepatocellular carcinoma
Circulating tumor-derived cell-free DNA (ctDNA) analysis offers an attractive noninvasive
means for detection and monitoring of cancers. Evidence for the presence of cancer is …
means for detection and monitoring of cancers. Evidence for the presence of cancer is …
Precision oncology in the age of integrative genomics
Precision oncology applies genomic and other molecular analyses of tumor biopsies to
improve the diagnosis and treatment of cancers. In addition to identifying therapeutic …
improve the diagnosis and treatment of cancers. In addition to identifying therapeutic …
Single-molecule sequencing enables long cell-free DNA detection and direct methylation analysis for cancer patients
Background Analysis of circulating tumor DNA has become increasingly important as a tool
for cancer care. However, the focus of previous studies has been on short fragments of DNA …
for cancer care. However, the focus of previous studies has been on short fragments of DNA …
Circulating tumor DNA: an emerging tool in gastrointestinal cancers
Circulating tumor DNA (ctDNA) is tumor-derived fragmented DNA in the bloodstream that
has come from primary or metastatic cancer sites. Neoplasm-specific genetic and epigenetic …
has come from primary or metastatic cancer sites. Neoplasm-specific genetic and epigenetic …
Shallow whole genome sequencing on circulating cell-free DNA allows reliable noninvasive copy-number profiling in neuroblastoma patients
N Van Roy, M Van Der Linden, B Menten… - Clinical Cancer …, 2017 - AACR
Purpose: Neuroblastoma (NB) is a heterogeneous disease characterized by distinct clinical
features and by the presence of typical copy-number alterations (CNAs). Given the strong …
features and by the presence of typical copy-number alterations (CNAs). Given the strong …