Short-chain fatty acids: linking diet, the microbiome and immunity

ER Mann, YK Lam, HH Uhlig - Nature Reviews Immunology, 2024 - nature.com
The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial
metabolites and their availability in the gut and other organs is determined by environmental …

Microbiota-mediated colonization resistance: mechanisms and regulation

G Caballero-Flores, JM Pickard, G Núñez - Nature Reviews …, 2023 - nature.com
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …

[HTML][HTML] Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: A review

J Chu, S Feng, C Guo, B Xue, K He, L Li - Biomedicine & …, 2023 - Elsevier
The gut microbiota is indispensable for maintaining host health by enhancing the host's
digestive capacity, safeguarding the intestinal epithelial barrier, and preventing pathogen …

Gut–liver axis: barriers and functional circuits

O Pabst, MW Hornef, FG Schaap, V Cerovic… - Nature Reviews …, 2023 - nature.com
The gut and the liver are characterized by mutual interactions between both organs, the
microbiome, diet and other environmental factors. The sum of these interactions is …

Dietary fiber and SCFAs in the regulation of mucosal immunity

JK Tan, L Macia, CR Mackay - Journal of allergy and clinical immunology, 2023 - Elsevier
Gut bacterial metabolites such as short-chain fatty acids (SCFAs) have important effects on
immune cells and the gut. SCFAs derive from the fermentation of dietary fiber by gut …

Gut microbiota and short chain fatty acids: implications in glucose homeostasis

P Portincasa, L Bonfrate, M Vacca… - International journal of …, 2022 - mdpi.com
Gut microbiota encompasses a wide variety of commensal microorganisms consisting of
trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with …

[HTML][HTML] Butyrate's role in human health and the current progress towards its clinical application to treat gastrointestinal disease

K Hodgkinson, F El Abbar, P Dobranowski… - Clinical Nutrition, 2023 - Elsevier
Butyrate is a key energy source for colonocytes and is produced by the gut microbiota
through fermentation of dietary fiber. Butyrate is a histone deacetylase inhibitor and also …

Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis

JA Rusch, BT Layden, LR Dugas - Frontiers in endocrinology, 2023 - frontiersin.org
Cognitive function in humans depends on the complex and interplay between multiple body
systems, including the hypothalamic-pituitary-adrenal (HPA) axis. The gut microbiota, which …

[HTML][HTML] Effect of diet and dietary components on the composition of the gut microbiota

A Beam, E Clinger, L Hao - Nutrients, 2021 - mdpi.com
Diet and dietary components have profound effects on the composition of the gut microbiota
and are among the most important contributors to the alteration in bacterial flora. This review …

[HTML][HTML] Microbial regulation of host physiology by short-chain fatty acids

B van der Hee, JM Wells - Trends in microbiology, 2021 - cell.com
Our ancestral diet consisted of much more nondigestible fiber than that of many societies
today. Thus, from an evolutionary perspective the human genome and its physiological and …