Glutamate and gamma-aminobutyric acid systems in the pathophysiology of major depression and antidepressant response to ketamine
In patients with major depressive disorder or bipolar disorder, abnormalities in excitatory
and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional …
and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional …
The neurobiology of depression and antidepressant action
We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …
Treatment of adult depression in the United States
Importance Despite recent increased use of antidepressants in the United States, concerns
persist that many adults with depression do not receive treatment, whereas others receive …
persist that many adults with depression do not receive treatment, whereas others receive …
Suicide-related events in patients treated with antiepileptic drugs
Background A previous meta-analysis of data from clinical trials showed an association
between antiepileptic drugs and suicidality (suicidal ideation, behavior, or both). We used …
between antiepileptic drugs and suicidality (suicidal ideation, behavior, or both). We used …
Myelin and oligodendrocyte lineage cell dysfunctions: New players in the etiology and treatment of depression and stress‐related disorders
Depressive disorders are complex, multifactorial disorders that have been traditionally
attributed exclusively to neuronal abnormalities. However, recent studies have increased …
attributed exclusively to neuronal abnormalities. However, recent studies have increased …
[HTML][HTML] Gabapentin therapy in psychiatric disorders: a systematic review
RK Berlin, PM Butler, MD Perloff - The primary care companion for …, 2015 - psychiatrist.com
Objective: Gabapentin is commonly used off-label in the treatment of psychiatric disorders
with success, failure, and controversy. A systematic review of the literature was performed to …
with success, failure, and controversy. A systematic review of the literature was performed to …
The antidepressant effect of ketamine is dampened by concomitant benzodiazepine medication
The rapid antidepressant effect of ketamine has become a breakthrough in the research and
treatment of depression. Although predictive and modulating factors of the response to …
treatment of depression. Although predictive and modulating factors of the response to …
Hippocampal GABAergic dysfunction in a rat chronic mild stress model of depression
In major depression, one line of research indicates that a dysfunctional GABAergic inhibitory
system is linked to the appearance of depressive symptoms. However, as the mechanistic …
system is linked to the appearance of depressive symptoms. However, as the mechanistic …
Effects of early long‐term treatment with antiepileptic drugs on development of seizures and depressive‐like behavior in a rat genetic absence epilepsy model
Purpose: Depression is most commonly associated with epilepsy. Recent reports have
suggested a putative relationship between seizure development and onset of depressive …
suggested a putative relationship between seizure development and onset of depressive …
[HTML][HTML] HCN channel targets for novel antidepressant treatment
Major depressive disorder (MDD) is a chronic and potentially life threatening illness that
carries a staggering global burden. Characterized by depressed mood, MDD is often difficult …
carries a staggering global burden. Characterized by depressed mood, MDD is often difficult …