In patients with major depressive disorder or bipolar disorder, abnormalities in excitatory
and/or inhibitory neurotransmission and neuronal plasticity may lead to aberrant functional …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Importance Despite recent increased use of antidepressants in the United States, concerns
persist that many adults with depression do not receive treatment, whereas others receive …

Background A previous meta-analysis of data from clinical trials showed an association
between antiepileptic drugs and suicidality (suicidal ideation, behavior, or both). We used …

Depressive disorders are complex, multifactorial disorders that have been traditionally
attributed exclusively to neuronal abnormalities. However, recent studies have increased …

The rapid antidepressant effect of ketamine has become a breakthrough in the research and
treatment of depression. Although predictive and modulating factors of the response to …

Objective: Gabapentin is commonly used off-label in the treatment of psychiatric disorders
with success, failure, and controversy. A systematic review of the literature was performed to …

Background RECOVER is a randomized sham-controlled trial of vagus nerve stimulation
and the largest such trial conducted with a psychiatric neuromodulation intervention …

In major depression, one line of research indicates that a dysfunctional GABAergic inhibitory
system is linked to the appearance of depressive symptoms. However, as the mechanistic …

Purpose: Depression is most commonly associated with epilepsy. Recent reports have
suggested a putative relationship between seizure development and onset of depressive …