The biologically relevant coordination chemistry of iron and nitric oxide: electronic structure and reactivity

N Lehnert, E Kim, HT Dong, JB Harland… - Chemical …, 2021 - ACS Publications
Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Nitric oxide and peroxynitrite in health and disease

P Pacher, JS Beckman, L Liaudet - Physiological reviews, 2007 - journals.physiology.org
The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

DS Bredt, SH Snyder - … of the National Academy of Sciences, 1990 - National Acad Sciences
Nitric oxide mediates vascular relaxing effects of endothelial cells, cytotoxic actions of
macrophages and neutrophils, and influences of excitatory amino acids on cerebellar cyclic …

Localization of nitric oxide synthase indicating a neural role for nitric oxide

DS Bredt, PM Hwang, SH Snyder - Nature, 1990 - nature.com
NITRIC oxide (NO), apparently identical to endothelium-derived relaxing factor in blood
vessels1–3, is also formed by cytotoxic macrophages4, 5, in adrenal gland6 and in brain …

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

DS Bredt, PM Hwang, CE Glatt, C Lowenstein… - Nature, 1991 - nature.com
Nitric oxide is a messenger molecule, mediating the effect of endothelium-derived relaxing
factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in …

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

VL Dawson, TM Dawson, ED London… - Proceedings of the …, 1991 - National Acad Sciences
Nitric oxide (NO) mediates several biological actions, including relaxation of blood vessels,
cytotoxicity of activated macrophages, and formation of cGMP by activation of glutamate …

Carbon monoxide: a putative neural messenger

A Verma, DJ Hirsch, CE Glatt, GV Ronnett, SH Snyder - Science, 1993 - science.org
Carbon monoxide, an activator of guanylyl cyclase, is formed by the action of the enzyme
heme oxygenase. By in situ hybridization in brain slices, discrete neuronal localization of …

Nitric oxide, a novel neuronal messenger

DS Bredt, SH Snyder - Neuron, 1992 - Elsevier
Nitric oxide (NO) is a free radical gas, clearly distinct from nitrous oxide, N20, which is used
as an anesthetic and is chemically stable. NO has long been known to occur in bacteria, but …

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide: implications for neurodegenerative diseases

MWJ Cleeter, JM Cooper, VM Darley-Usmar… - FEBS letters, 1994 - Elsevier
Incubation of rat skeletal muscle mitochondria with the nitric oxide generator, S-
nitrosoglutathione (GSNO) reversibly inhibited oxygen utilisation with all substrates tested …

d-Serine is an endogenous ligand for the glycine site of the N-methyl-d-aspartate receptor

JP Mothet, AT Parent, H Wolosker… - Proceedings of the …, 2000 - National Acad Sciences
Functional activity of N-methyl-d-aspartate (NMDA) receptors requires both glutamate
binding and the binding of an endogenous coagonist that has been presumed to be glycine …