From embryonic development to wound repair, concentration gradients of bioactive
signaling molecules guide tissue formation and regeneration. Moreover, gradients in cellular …

Material engineering methods have been used for many years to develop biomedical
devices for use within the body to augment, repair or replace damaged tissues ranging from …

Combinatorial and high throughput (HTP) methodologies have long been used by the
pharmaceutical industry to accelerate the rate of drug discovery. HTP techniques can also …

Chronic inflammation-mediated oxidative stress is a common mechanism of implant
rejection and failure. Therefore, polymer scaffolds that can degrade slowly in response to …

This paper presents the results of a combined experimental and analytical study of blended
FDA-approved polymers [polylactic-co-glycolic acid (PLGA), polyethylene glycol (PEG) and …

The increasing interest in studying cells using more in vivo-like three-dimensional (3D)
microenvironments has created a need for advanced 3D screening platforms with enhanced …

Inserting a graft into vessels with different diameters frequently causes severe damage to the
host vessels. Poor flow patency is an unresolved issue in grafts, particularly those with …

Vascular tissue possesses numerous nanostructured surface features, but most metallic
vascular stents proposed to restore blood flow are smooth at the nanoscale. Thus, the …

At present the manufacture of small-diameter blood vessels is one of the main challenges in
the field of vascular tissue engineering. Currently available vascular grafts rapidly fail due to …

In the body, vascular cells continuously interact with tissues that possess nanostructured
surface features due to the presence of proteins (such as collagen and elastin) embedded in …