Microglia are the resident macrophage population of the central nervous system (CNS).
Adequate microglial function is crucial for a healthy CNS. Microglia are not only the first …

Developmental hematopoiesis consists of multiple, partially overlap** hematopoietic
waves that generate the differentiated blood cells required for embryonic development while …

The production of megakaryocytes (MKs)—the precursors of blood platelets—from human
pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine …

Despite the increasing importance of long noncoding RNA in physiology and disease, their
role in endothelial biology remains poorly understood. Growing evidence has highlighted …

Hematopoietic stem cell transplantation (HSCT) is the first field where human stem cell
therapy was successful. Flooding interest on human stem cell therapy to cure previously …

Advancements in human pluripotent stem cell (hPSC) research have potential to
revolutionize therapeutic transplantation. It has been demonstrated that transcription factors …

Generating human hematopoietic stem cells (HSCs) from autologous tissues, when coupled
with genome editing technologies, is a promising approach for cellular transplantation …

The molecular determinants regulating the specification of human embryonic stem cells
(hESCs) into hematopoietic cells remain elusive. HOXA9 plays a relevant role in …

TAL1 (SCL/TAL1, T-cell acute leukemia protein 1) is a transcription factor that is involved in
the process of hematopoiesis and leukemogenesis. It participates in blood cell formation …

Previous attempts to either generate or expand hematopoietic stem cells (HSCs) in vitro
have involved either ex vivo expansion of pre-existing patient or donor HSCs or de novo …