PARP inhibitors: clinical relevance, mechanisms of action and tumor resistance
The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular
processes, including the regulation of transcription, apoptosis and the DNA damage …
processes, including the regulation of transcription, apoptosis and the DNA damage …
[HTML][HTML] Evolving concepts in NAD+ metabolism
Summary NAD (H) and NADP (H) have traditionally been viewed as co-factors (or co-
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …
enzymes) involved in a myriad of oxidation-reduction reactions including the electron …
Targeting senescent cells for a healthier aging: challenges and opportunities
S Song, T Tchkonia, J Jiang, JL Kirkland… - Advanced …, 2020 - Wiley Online Library
Aging is a physiological decline in both structural homeostasis and functional integrity,
progressively affecting organismal health. A major hallmark of aging is the accumulation of …
progressively affecting organismal health. A major hallmark of aging is the accumulation of …
Map** physiological ADP-ribosylation using activated ion electron transfer dissociation
ADP-ribosylation (ADPr) is a post-translational modification that plays pivotal roles in a wide
range of cellular processes. Mass spectrometry (MS)-based analysis of ADPr under …
range of cellular processes. Mass spectrometry (MS)-based analysis of ADPr under …
[HTML][HTML] Disruption of nuclear envelope integrity as a possible initiating event in tauopathies
M Prissette, W Fury, M Koss, C Racioppi, D Fedorova… - Cell reports, 2022 - cell.com
The microtubule-associated protein tau is an abundant component of neurons of the central
nervous system. In Alzheimer's disease and other neurodegenerative tauopathies, tau is …
nervous system. In Alzheimer's disease and other neurodegenerative tauopathies, tau is …
The potential of PARP inhibitors in targeted cancer therapy and immunotherapy
J Hunia, K Gawalski, A Szredzka… - Frontiers in molecular …, 2022 - frontiersin.org
DNA damage response (DDR) deficiencies result in genome instability, which is one of the
hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various …
hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various …
Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex
Small nucleolar RNAs (snoRNAs) are commonly acknowledged as a class of homogeneous
non-coding RNAs that guide ribosomal RNA modifications. However, snoRNAs referred to …
non-coding RNAs that guide ribosomal RNA modifications. However, snoRNAs referred to …
Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis
Abstract Centromere defects in Systemic Sclerosis (SSc) have remained unexplored despite
the fact that many centromere proteins were discovered in patients with SSc. Here we report …
the fact that many centromere proteins were discovered in patients with SSc. Here we report …
The fructose-bisphosphate, Aldolase A (ALDOA), facilitates DNA-PKcs and ATM kinase activity to regulate DNA double-strand break repair
Glucose metabolism and DNA repair are fundamental cellular processes frequently
dysregulated in cancer. In this study, we define a direct role for the glycolytic Aldolase A …
dysregulated in cancer. In this study, we define a direct role for the glycolytic Aldolase A …
Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners
A Marcelot, A Petitalot, V Ropars, MH Le Du… - Nucleic acids …, 2021 - academic.oup.com
Barrier-to-autointegration factor (BAF), encoded by the BANF1 gene, is an abundant and
ubiquitously expressed metazoan protein that has multiple functions during the cell cycle …
ubiquitously expressed metazoan protein that has multiple functions during the cell cycle …