Antioxidant phytochemicals as potential therapy for diabetic complications

OOP Akpoveso, EE Ubah, G Obasanmi - Antioxidants, 2023 - mdpi.com
The global prevalence of diabetes continues to increase partly due to rapid urbanization and
an increase in the aging population. Consequently, this is associated with a parallel …

The effect of polyphenols on kidney disease: Targeting mitochondria

F Ashkar, KS Bhullar, J Wu - Nutrients, 2022 - mdpi.com
Mitochondrial function, including oxidative phosphorylation (OXPHOS), mitochondrial
biogenesis, and mitochondria dynamics, are essential for the maintenance of renal health …

Ellagic acid alleviates oxidative stress by mediating Nrf2 signaling pathways and protects against paraquat-induced intestinal injury in piglets

Y **ao, R Huang, N Wang, Y Deng, B Tan, Y Yin, M Qi… - Antioxidants, 2022 - mdpi.com
The gastrointestinal tract is a key source of superoxide so as to be one of the most
vulnerable to oxidative stress damage. Ellagic acid (EA), a polyphenol displays widely …

Dietary ellagic acid ameliorated Clostridium perfringens-induced subclinical necrotic enteritis in broilers via regulating inflammation and cecal microbiota

Y Tang, X Zhang, Y Wang, Y Guo, P Zhu, G Li… - Journal of animal …, 2022 - Springer
Background Subclinical necrotic enteritis (SNE), a common intestinal disease of broiler
caused by Clostridium perfringens, could reduce production performance of broilers by …

Ellagic acid protects against non-alcoholic fatty liver disease in streptozotocin-diabetic rats by activating AMPK

JZ ALTamimi, GM Alshammari, NA AlFaris… - Pharmaceutical …, 2022 - Taylor & Francis
Context Ellagic acid (EA) is used in traditional medicine to treated hyperlipidaemia.
Objective This study examined if AMPK mediates the anti-steatotic effect of ellagic acid (EA) …

Ellagic acid ameliorates aging-induced renal oxidative damage through upregulating SIRT1 and NRF2

N Naghibi, A Sadeghi, S Movahedinia… - … medicine and therapies, 2023 - Springer
Background Aging is associated with impaired renal function and structural alterations.
Oxidative stress plays a vital role in renal senescence and damage. Sirtuin 1 (SIRT1) is …

Ellagic acid as potential therapeutic compound for diabetes and its complications: a systematic review from bench to bed

H Ghazaee, A Raouf Sheibani, H Mahdian… - Naunyn-Schmiedeberg's …, 2024 - Springer
Diabetes mellitus (DM) is a worldwide-concerning disease with a rising prevalence. There
are many ongoing studies aimed at finding new and effective treatments. Ellagic acid (EA) is …

Antioxidant activities of natural compounds from Caribbean plants to enhance diabetic wound healing

L Accipe, A Abadie, R Neviere, S Bercion - Antioxidants, 2023 - mdpi.com
Diabetic wound healing is a global medical challenge. Several studies showed that delayed
healing in diabetic patients is multifactorial. Nevertheless, there is evidence that excessive …

Synergistic effects of sinapic acid and ellagic acid ameliorate streptozotocin-induced diabetic nephropathy by inhibiting apoptosis, DNA damage, and structural …

F Altındağ, U Özdek - Human & Experimental Toxicology, 2021 - journals.sagepub.com
Introduction Diabetic nephropathy (DN), a global problem that threatens human health, is an
important reason for chronic kidney disease and kidney failure. In our study, it was aimed to …

Potential Nephroprotective Effect of Kaempferol: Biosynthesis, Mechanisms of Action, and Clinical Prospects

MY Alkandahri, A Sadino… - Advances in …, 2024 - Wiley Online Library
Kidney is an essential organ that is highly susceptible to cellular injury caused by various
toxic substances in the blood. Several studies have shown that untreated injuries to this …