Recombinant interferon‐α (IFN‐α) was approved by regulatory agencies in many countries
in 1986. As the first biotherapeutic approved, IFN‐α paved the way for the development of …

Resveratrol (3, 4′, 5-trans-trihydroxystilbene), a naturally occurring stilbene, is considered
to have a number of beneficial effects, including anticancer, anti-aethrogenic, anti-oxidative …

Signal transducer and activator of transcription‐3 (STAT‐3) is one of six members of a family
of transcription factors. It was discovered almost 15 years ago as an acute‐phase response …

Resveratrol is a cancer preventative agent that is found in red wine. Piceatannol is a closely
related stilbene that has antileukaemic activity and is also a tyrosine kinase inhibitor …

Recent evidence indicates a convergence of molecular targets for both prevention and
therapy of cancer. Signal‐transducer‐and‐activator‐of‐transcription‐3 (STAT3), a member …

Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality
worldwide. Unhealthy dietary habits have clearly been shown to contribute to the …

Since in most tumors multiple signaling pathways are involved, many of the inhibitors in
clinical development are designed to affect a wide range of targeted kinases. The most …

Non-receptor type of protein-tyrosine kinase Syk contains 2 Src homology 2 (SH2) domains
in tandem and multiple autophosphorylation sites. Syk is activated upon binding of tandem …

Current cancer therapies are highly toxic and often nonspecific. A potentially less toxic
approach to treating this prevalent disease employs agents that modify cancer cell …

Abstract Development of the chimeric mouse antihuman CD20 antibody, Rituximab,
presented a notable advance in the treatment of patients with non-Hodgkin's lymphoma …