Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …

BACKGROUND Neurons are polarized cells with extreme geometries. Multiple dendrites
and one axon generally emerge from a single cell body and establish synaptic contacts with …

Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into
insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia, yet the …

Intermediate filaments (IFs) are integral components of the cytoskeleton. They provide cells
with tissue-specific mechanical properties and are involved in numerous cellular processes …

The cilium-centrosome complex contains triplet, doublet, and singlet microtubules. The
lumenal surfaces of each microtubule within this diverse array are decorated by microtubule …

The repeating arrangement of tubulin dimers confers great mechanical strength to
microtubules, which are used as scaffolds for intracellular macromolecular transport in cells …

In living cells, microtubules (MTs) play pleiotropic roles, which require very different
mechanical properties. Unlike the dynamic MTs found in the cytoplasm of metazoan cells …

Primary cilia are microtubule-based organelles that are important for signaling and sensing
in eukaryotic cells. Unlike the thoroughly studied motile cilia, the three-dimensional …

Tau protein in vitro can undergo liquid–liquid phase separation (LLPS); however,
observations of this phase transition in living cells are limited. To investigate protein state …

Microtubules (MTs) are polymers of αβ-tubulin heterodimers that stochastically switch
between growth and shrinkage phases. This dynamic instability is critically important for MT …