[HTML][HTML] Overview of neurological mechanism of pain profile used for animal “pain-like” behavioral study with proposed analgesic pathways

MF Yam, YC Loh, CW Oo, R Basir - International journal of molecular …, 2020 - mdpi.com
Pain is the most common sensation installed in us naturally which plays a vital role in
defending us against severe harm. This neurological mechanism pathway has been one of …

[PDF][PDF] A detailed review on nociceptive models for the screening of analgesic activity in experimental animals

PK Patel, J Sahu, SS Chandel - International Journal of …, 2016 - researchgate.net
Pain is an unpleasant sensation, which informs about any abnormality in either body or part
of it. Pain may be either physical or mental depending on its source of origin. Generally …

Evaluation of Analgesic and Anti-inflammatory Activities of Methanolic Leaf and Root Extracts of Gomphocarpus purpurascens A. Rich (Asclepiadaceae) in Mice

MA Ayanaw, JS Yesuf, EM Birru - Journal of Experimental …, 2023 - Taylor & Francis
Background Regardless of the availability of drugs many people still experienced pain and
inflammation because current medications often trigger potentially serious adverse effects. A …

[HTML][HTML] Synthesis and investigation of the analgesic potential of enantiomerically pure schiff bases: a mechanistic approach

HH Afridi, M Shoaib, FA Al-Joufi, SWA Shah, H Hussain… - Molecules, 2022 - mdpi.com
Schiff bases are a class of organic compounds with azomethine moiety, exhibiting a wide
range of biological potentials. In this research, six chiral Schiff bases, three 'S'series (H1 …

Anti-inflammatory and analgesic activities of solvent fractions of the leaves of Moringa stenopetala Bak. (Moringaceae) in mice models

Y Tamrat, T Nedi, S Assefa, T Teklehaymanot… - … and alternative medicine, 2017 - Springer
Background Many people still experience pain and inflammation regardless of the available
drugs for treatments. In addition, the available drugs have many side effects, which …

Comparison of electroencephalographic changes in response to acute electrical and thermal stimuli with the tail flick and hot plate test in rats administered with …

P Singh, K Kongara, D Harding, N Ward… - BMC neurology, 2018 - Springer
Background The objective of this study was to compare the changes in the
electroencephalogram (EEG) in response to noxious stimuli with tail flick and hot plate …

[HTML][HTML] In vivo and in vitro evaluation of pharmacological activities of Adenia trilobata (Roxb.)

N Barua, MAI Aziz, AM Tareq, MA Sayeed… - … and Biophysics Reports, 2020 - Elsevier
Adenia trilobata, locally known as akandaphal in Bangladesh, has some traditional uses.
Leaves and stems extracted with pure methanol (MEATL, MEATS) and fractioned by n …

Antinociceptive effect of tadalafil in various pain models: Involvement of opioid receptors and nitric oxide cyclic GMP pathway

MM Mehanna, S Domiati, HN Chmaisse… - Toxicology and applied …, 2018 - Elsevier
Nitric oxide has been proven to play an important role in nociception, accordingly, its
promoters, phosphodiesterase inhibitors have been investigated as pain response …

[HTML][HTML] The possible mechanisms of protocatechuic acid-induced central analgesia

R Arslan, S Aydin, DN Samur, N Bektas - Saudi pharmaceutical journal, 2018 - Elsevier
It is aimed to investigate the central antinociceptive effect of protocatechuic acid and the
involvement of stimulation of opioidergic, serotonin 5-HT 2A/2C, α2-adrenergic and …

Preclinical screening of Phyllanthus amarus ethanolic extract for its analgesic and antimicrobial activity

SS Bhat, KS Hegde, S Chandrashekhar… - Pharmacognosy …, 2015 - pmc.ncbi.nlm.nih.gov
Background: To discover a new agent which possesses dual property of analgesic and
antimicrobial activity, thereby reducing the burden of polypharmacy. Phyllanthus amarus …