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Unraveling the interplay of kinesin-1, tau, and microtubules in neurodegeneration associated with Alzheimer's disease
Alzheimer's disease (AD) is marked by the gradual and age-related deterioration of nerve
cells in the central nervous system. The histopathological features observed in the brain …
cells in the central nervous system. The histopathological features observed in the brain …
Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ‐Secretase Modulator
Objective The retromer complex plays an essential role in intracellular endosomal sorting.
Deficits in the retromer complex are linked to enhanced Aβ production. The levels of the …
Deficits in the retromer complex are linked to enhanced Aβ production. The levels of the …
Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene …
Introduction Synaptic failure, a hallmark of Alzheimer's disease (AD), is correlated with
reduced levels of synaptic proteins. Though people with Down syndrome (DS) are at …
reduced levels of synaptic proteins. Though people with Down syndrome (DS) are at …
Forebrain commissure formation in zebrafish embryo requires the binding of KLC1 to CRMP2
S Li, Y Guo, M Takahashi, H Suzuki… - Developmental …, 2024 - Wiley Online Library
Formation of the corpus callosum (CC), anterior commissure (AC), and postoptic
commissure (POC), connecting the left and right cerebral hemispheres, is crucial for cerebral …
commissure (POC), connecting the left and right cerebral hemispheres, is crucial for cerebral …
[HTML][HTML] Alzheimer's disease is associated with disruption in thiamin transport physiology: a potential role for neuroinflammation
K Ramamoorthy, R Yoshimura, S Al-Juburi… - Neurobiology of …, 2022 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease characterized by Amyloid-β
peptide (Aβ) containing plaques and cognitive deficits. The pathophysiology of AD also …
peptide (Aβ) containing plaques and cognitive deficits. The pathophysiology of AD also …
[HTML][HTML] Swedish Alzheimer's disease variant perturbs activity of retrograde molecular motors and causes widespread derangement of axonal transport pathways
Experimental studies in flies, mice, and humans suggest a significant role of impaired axonal
transport in the pathogenesis of Alzheimer's disease (AD). The mechanisms underlying …
transport in the pathogenesis of Alzheimer's disease (AD). The mechanisms underlying …
[HTML][HTML] Gene-gene functional relationships in Alzheimer's disease: CELF1 regulates KLC1 alternative splicing
M Kikuchi, J Viet, K Nagata, M Sato, G David… - Biochemical and …, 2024 - Elsevier
The causes of Alzheimer's disease (AD) are poorly understood, although many genes are
known to be involved in this pathology. To gain insights into the underlying molecular …
known to be involved in this pathology. To gain insights into the underlying molecular …
Transcriptome‐wide association identifies KLC1 as a regulator of mitophagy in non‐syndromic cleft lip with or without palate
S Lou, G Zhu, C **ng, S Hao, J Lin, J Xu, D Li, Y Du… - Imeta, 2024 - Wiley Online Library
To the Editor, Non‐syndromic cleft lip with or without palate (NSCL/P) is one of the most
prevalent congenital craniofacial anomalies, affecting approximately one in 700 live births …
prevalent congenital craniofacial anomalies, affecting approximately one in 700 live births …
Missorting of plasma miRNAs in aging and Alzheimer's disease
M Čarna, JS Novotny, N Dragišić… - Journal of …, 2023 - Wiley Online Library
The observation that aging is regulated by microRNAs (miRNA) and at the same time
represents the greatest risk factor for Alzheimer's disease (AD), prompted us to examine the …
represents the greatest risk factor for Alzheimer's disease (AD), prompted us to examine the …
Group-shrinkage feature selection with a spatial network for mining DNA methylation data
Identifying disease-related biomarkers from high-dimensional DNA methylation data helps
in reducing early screening costs and inferring pathogenesis mechanisms. Good discovery …
in reducing early screening costs and inferring pathogenesis mechanisms. Good discovery …