Anemia at older age: etiologies, clinical implications, and management

R Stauder, P Valent, I Theurl - Blood, The Journal of the …, 2018 - ashpublications.org
Anemia is quite frequently diagnosed in older individuals and is a key indicator of various
reactive and clonal conditions. Many underlying diseases, like myelodysplastic syndrome …

The relationship between erythrocytes and diabetes mellitus

Y Wang, P Yang, Z Yan, Z Liu, Q Ma… - Journal of Diabetes …, 2021 - Wiley Online Library
High blood glucose level (hyperglycemia) is a leading indicator of diabetes mellitus (DM).
Erythrocytes are the most abundant cells in the circulation and the first to perceive changes …

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …

DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases

R Bissinger, AAM Bhuyan, SM Qadri… - The FEBS …, 2019 - Wiley Online Library
The average lifespan of circulating erythrocytes usually exceeds hundred days. Prior to that,
however, erythrocytes may be exposed to oxidative stress in the circulation which could …

Molecular mechanisms and pathophysiological significance of eryptosis

SA Alghareeb, MA Alfhili, S Fatima - International Journal of Molecular …, 2023 - mdpi.com
Despite lacking the central apoptotic machinery, senescent or damaged RBCs can undergo
an unusual apoptosis-like cell death, termed eryptosis. This premature death can be caused …

Red blood cells: chasing interactions

V Pretini, MH Koenen, L Kaestner, MHAM Fens… - Frontiers in …, 2019 - frontiersin.org
Human red blood cells (RBC) are highly differentiated cells that have lost all organelles and
most intracellular machineries during their maturation process. RBC are fundamental for the …

Metabolic influences modulating erythrocyte deformability and eryptosis

JF Brun, E Varlet-Marie, J Myzia… - Metabolites, 2021 - mdpi.com
Many factors in the surrounding environment have been reported to influence erythrocyte
deformability. It is likely that some influences represent reversible changes in erythrocyte …

Platelet activity and hypercoagulation in type 2 diabetes

L Pretorius, GJA Thomson, RCM Adams… - Cardiovascular …, 2018 - Springer
Background A strong correlation exists between type 2 diabetes mellitus (T2DM) and
cardiovascular disease (CVD), with CVD and the presence of atherosclerosis being the …

[HTML][HTML] Proteinuric chronic kidney disease is associated with altered red blood cell lifespan, deformability and metabolism

R Bissinger, T Nemkov, A D'Alessandro, M Grau… - Kidney international, 2021 - Elsevier
Anemia is a common complication of chronic kidney disease, affecting the quality of life of
patients. Among various factors, such as iron and erythropoietin deficiency, reduced red …

Erythrocytes as model cells for biocompatibility assessment, cytotoxicity screening of xenobiotics and drug delivery

M Podsiedlik, M Markowicz-Piasecka… - Chemico-Biological …, 2020 - Elsevier
Erythrocytes (RBCs) represent the main cell component in circulation and recently have
become a topic of intensive scientific interest. The relevance of erythrocytes as a model for …