Intervertebral disc (IVD) degeneration is a complicated process that involves both age-
related change and tissue damage caused by multiple stresses. In a degenerative IVD …

The accumulation of senescent disc cells in degenerative intervertebral disc (IVD) suggests
the detrimental roles of cell senescence in the pathogenesis of intervertebral disc …

Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's
declining function and the development of pain, it may affect one's physical health, mental …

BACKGROUND CONTEXT: Degeneration and injuries of the intervertebral disc (IVD) result
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …

Background: Several cell-based therapies have been proposed in recent years the
management of low back pain, including the injection of medicinal signaling cells or …

The metabolic environment of disc cells is governed by the avascular nature of the tissue.
Because cellular energy metabolism occurs mainly through glycolysis, the disc cells require …

Low back pain (LBP) is a chronic condition that can affect up to 80% of the global
population. It is the number one cause of disability worldwide and has enormous …

Low back pain (LBP) is often associated with the degeneration of human intervertebral discs
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …

Aetiology of intervertebral disc degeneration (IDD) is complex, with genetic, developmental,
biochemical and biomechanical factors contributing to the disease process. It is becoming …

Study Design. In vivo study of the effect of injection of osteogenic protein-1 (OP-1) on a
rabbit anular needle puncture model of intervertebral disc (IVD) degeneration. Objective. To …