Cancer is a condition that has plagued humanity for thousands of years, with the first
depictions dating back to ancient Egyptian times. However, not until recent decades have …

The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic
alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK) …

Cancer is a major public health concern due to high mortality and poor quality of life of
patients. Despite the availability of advanced therapeutic interventions, most treatment …

Incorporation of T1 and T2 contrast material in one nanosystem performing their respective
MR contrast role and simultaneously serving as an efficient drug delivery system (DDS) has …

Nephrotoxicity is a major adverse effect in cisplatin chemotherapy, and renoprotective
approaches are unavailable. Recent work unveiled a critical role of protein kinase Cδ …

DNA damage activates specific cell signaling cascades for DNA repair, cell cycle arrest,
senescence, and/or cell death. Recent studies have demonstrated DNA damage response …

It is anticipated that by 2030 approximately 13 million people will die of cancer. Common
cancer therapy often fails due to the development of multidrug resistance (MDR), resulting in …

The organometallic “half-sandwich” compound [Os (η6-p-cymene)(4-(2-pyridylazo)-N, N-
dimethylaniline) I] PF6 is 49× more potent than the clinical drug cisplatin in the 809 cancer …

Purpose This study was performed to compare the efficacies and toxicities of cisplatin
(CDDP)-and carboplatin (CBDCA)-based chemotherapy (CT) in patients with SCCHN …

Ovarian cancer is the fifth leading cause of cancer-related female deaths. Due to serious
side effects, relapse and resistance to standard chemotherapy, better and more targeted …