Intravenous immunoglobulin therapy: how does IgG modulate the immune system?
I Schwab, F Nimmerjahn - Nature Reviews Immunology, 2013 - nature.com
Intravenous immunoglobulin (IVIG) preparations comprise pooled IgG antibodies from the
serum of thousands of donors and were initially used as an IgG replacement therapy in …
serum of thousands of donors and were initially used as an IgG replacement therapy in …
Maternal antibodies: clinical significance, mechanism of interference with immune responses, and possible vaccination strategies
S Niewiesk - Frontiers in immunology, 2014 - frontiersin.org
Neonates have an immature immune system, which cannot adequately protect against
infectious diseases. Early in life, immune protection is accomplished by maternal antibodies …
infectious diseases. Early in life, immune protection is accomplished by maternal antibodies …
Novel therapies for immune-mediated inflammatory diseases: what can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus …
The past three decades have witnessed remarkable advances in our ability to target specific
elements of the immune and inflammatory response, fuelled by advances in both …
elements of the immune and inflammatory response, fuelled by advances in both …
The ITP syndrome: pathogenic and clinical diversity
Immune thrombocytopenia (ITP) is mediated by platelet autoantibodies that accelerate
platelet destruction and inhibit their production. Most cases are considered idiopathic …
platelet destruction and inhibit their production. Most cases are considered idiopathic …
The molecular mechanisms that underlie the immune biology of anti-drug antibody formation following treatment with monoclonal antibodies
A Vaisman-Mentesh, M Gutierrez-Gonzalez… - Frontiers in …, 2020 - frontiersin.org
Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …
however, the repeated administration of mAbs can be highly immunogenic. Drug …
IVIG-mediated effector functions in autoimmune and inflammatory diseases
Intravenous immunoglobulin (IVIG) is a pooled preparation of normal IgG obtained from
several thousand healthy donors. It is widely used in the immunotherapy of a large number …
several thousand healthy donors. It is widely used in the immunotherapy of a large number …
[HTML][HTML] Adeno-associated viral vector-mediated immune responses: Understanding barriers to gene delivery
NF Nidetz, MC McGee, VT Long**, C Li… - Pharmacology & …, 2020 - Elsevier
Adeno-associated viral (AAV) vectors have emerged as the leading gene delivery platform
for gene therapy and vaccination. Three AAV-based gene therapy drugs, Glybera …
for gene therapy and vaccination. Three AAV-based gene therapy drugs, Glybera …
Immunogenicity of TNF-inhibitors
S Atiqi, F Hooijberg, FC Loeff, T Rispens… - Frontiers in …, 2020 - frontiersin.org
Tumor necrosis factor inhibitors (TNFi) have significantly improved treatment outcome of
rheumatic diseases since their incorporation into treatment protocols two decades ago …
rheumatic diseases since their incorporation into treatment protocols two decades ago …
Antibody response to infliximab and its impact on pharmacokinetics can be transient
NV Casteele, A Gils, S Singh, L Ohrmund… - Official journal of the …, 2013 - journals.lww.com
OBJECTIVES: Infliximab (IFX) is successfully used in the treatment of inflammatory bowel
diseases but some patients generate antibodies to IFX (ATI) jeopardizing the …
diseases but some patients generate antibodies to IFX (ATI) jeopardizing the …
Assessing developability early in the discovery process for novel biologics
Beyond potency, a good developability profile is a key attribute of a biological drug.
Selecting and screening for such attributes early in the drug development process can save …
Selecting and screening for such attributes early in the drug development process can save …