Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, with
several underlying pathophysiological mechanisms, some of which are still uncertain. The …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

As the biological alarm of impending or actual tissue damage, pain is essential for our
survival. However, when it is initiated and/or sustained by dysfunctional elements in the …

As the cornea is densely innervated, its nerves are integral not only to its structure but also to
its pathophysiology. Corneal integrity depends on a protective tear film that is maintained by …

Undoubtedly, adjusting our thermoregulatory behavior represents the most effective
mechanism to maintain thermal homeostasis and ensure survival in the diverse thermal …

Dry eye disease (DED) is a multifactorial disorder in which the eyes respond to minor stimuli
with abnormal sensations, such as dryness, blurring, foreign body sensation, discomfort …

Although the ability to sense skin wetness and humidity is critical for behavioral and
autonomic adaptations, humans are not provided with specific skin receptors for sensing …

Purpose: Persistent ocular surface pain occurs in moderate to severe dry eye disease (DE);
however, the mechanisms that underlie this symptom remain uncertain. The aim of this study …

Purpose: To define the firing properties of sensory nerve terminals innervating the adult
mouse cornea in response to external stimuli of differing modality. Methods: Extracellular …