Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-
inflammatory effects, they have been amongst the most widely used and effective treatments …

Nuclear receptors (NRs) are a family of transcription factors that regulate numerous
physiological processes such as metabolism, reproduction, inflammation, as well as the …

In order to obtain a novel binding protein against a chosen target, DNA molecules, each
encoding a protein comprising one of a family of similar potential binding domains and a …

The zinc finger DNA-binding motif occurs in many proteins that regulate eukaryotic gene
expression. The crystal structure of a complex containing the three zinc fingers from Zif268 …

The crystal structure of bovine heart cytochrome c oxidase at 2.8 Å resolution with an R
value of 19.9 percent reveals 13 subunits, each different from the other, five phosphatidyl …

Gene regulation by steroid hormones has been a traditional field of research for biochemical
endocrinology since the discovery of puff induction by ecdysone in giant chromosomes of …

The nuclear hormone receptor superfamily includes receptors for thyroid and steroid
hormones, retinoids and vitamin D, as well as different “orphan” receptors of unknown …

I. Introduction IN 1953 lohn Morris, an obstetrician at Yale University, reported a series of 82
individuals (80 cases collated from the literature and two cases of his own) who had a …

Nuclear targeting sequences are essential for the transport of proteins into the nucleus. The
seven-amino-acid nuclear targeting sequence of the SV40 large T antigen has been …

Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with
DNA are reported. The domain has a globular fold which contains two Zn-nucleated …