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Cell contraction induces long-ranged stress stiffening in the extracellular matrix
Animal cells in tissues are supported by biopolymer matrices, which typically exhibit highly
nonlinear mechanical properties. While the linear elasticity of the matrix can significantly …
nonlinear mechanical properties. While the linear elasticity of the matrix can significantly …
Fiber networks amplify active stress
Large-scale force generation is essential for biological functions such as cell motility,
embryonic development, and muscle contraction. In these processes, forces generated at …
embryonic development, and muscle contraction. In these processes, forces generated at …
High strain-rate soft material characterization via inertial cavitation
Mechanical characterization of soft materials at high strain-rates is challenging due to their
high compliance, slow wave speeds, and non-linear viscoelasticity. Yet, knowledge of their …
high compliance, slow wave speeds, and non-linear viscoelasticity. Yet, knowledge of their …
Microbuckling of fibrin provides a mechanism for cell mechanosensing
Biological cells sense and respond to mechanical forces, but how such a mechanosensing
process takes place in a nonlinear inhomogeneous fibrous matrix remains unknown. We …
process takes place in a nonlinear inhomogeneous fibrous matrix remains unknown. We …
Nonlinear elasticity of the ECM fibers facilitates efficient intercellular communication
Biological cells embedded in fibrous matrices have been observed to form intercellular
bands of dense and aligned fibers through which they mechanically interact over long …
bands of dense and aligned fibers through which they mechanically interact over long …
[HTML][HTML] A new computational framework for materials with different mechanical responses in tension and compression and its applications
Materials possessing tension-compression asymmetric behavior can be simulated by a bi-
modulus constitutive relation, which assumes the materials have different moduli in tension …
modulus constitutive relation, which assumes the materials have different moduli in tension …
Continuum elastic models for force transmission in biopolymer gels
We review continuum elastic models for the transmission of both external forces and internal
active cellular forces in biopolymer gels, and relate them to recent experiments. Rather than …
active cellular forces in biopolymer gels, and relate them to recent experiments. Rather than …
Elastic anisotropy governs the range of cell-induced displacements
The unique nonlinear mechanics of the fibrous extracellular matrix (ECM) facilitates long-
range cell-cell mechanical communications that would be impossible for linear elastic …
range cell-cell mechanical communications that would be impossible for linear elastic …
Unexpected softening of a fibrous matrix by contracting inclusions
Cells respond to the stiffness of their surrounding environment, but quantifying the stiffness
of a fibrous matrix at the scale of a cell is complicated, due to the effects of nonlinearity and …
of a fibrous matrix at the scale of a cell is complicated, due to the effects of nonlinearity and …
Tension-compression asymmetry at finite strains: A theoretical model and exact solutions
Besides being ubiquitous in engineering applications such as Polyethylene terephthalate,
materials with tension-compression asymmetry can also be found in lots of biological …
materials with tension-compression asymmetry can also be found in lots of biological …