Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that
regulate lipid biosynthesis and adipogenesis by controlling the expression of several …

Cells sense their physical surroundings through mechanotransduction—that is, by
translating mechanical forces and deformations into biochemical signals such as changes in …

Morphogenesis is the remarkable process by which cells self-assemble into complex tissues
and organs that exhibit specialized form and function during embryological development …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

Essentially all organisms from bacteria to humans are mechanosensitive. Physical forces
regulate a large array of physiological processes, and dysregulation of mechanical …

Forces are increasingly recognized as major regulators of cell structure and function, and
the mechanical properties of cells are essential to the mechanisms by which cells sense …

Mechanical loads induce changes in the structure, composition, and function of living
tissues. Cells in tissues are responsible for these changes, which cause physiological or …

A hostile myocardial microenvironment post ischemic injury (myocardial infarction) plays a
decisive role in determining the fate of tissue-engineered approaches. Therefore …