The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges

CY Loh, JY Chai, TF Tang, WF Wong, G Sethi… - Cells, 2019 - mdpi.com
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …

Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications

BN Singh, S Shankar, RK Srivastava - Biochemical pharmacology, 2011 - Elsevier
An expanding body of preclinical evidence suggests EGCG, the major catechin found in
green tea (Camellia sinensis), has the potential to impact a variety of human diseases …

[HTML][HTML] An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules

A Basu, NE Bodycombe, JH Cheah, EV Price, K Liu… - Cell, 2013 - cell.com
The high rate of clinical response to protein-kinase-targeting drugs matched to cancer
patients with specific genomic alterations has prompted efforts to use cancer cell line (CCL) …

Cancer prevention by tea: animal studies, molecular mechanisms and human relevance

CS Yang, X Wang, G Lu, SC Picinich - Nature Reviews Cancer, 2009 - nature.com
Extracts of tea, especially green tea, and tea polyphenols have been shown to inhibit the
formation and development of tumours at different organ sites in animal models. There is …

Tea polyphenols for health promotion

N Khan, H Mukhtar - Life sciences, 2007 - Elsevier
People have been consuming brewed tea from the leaves of the Camellia sinensis plant for
almost 50 centuries. Although health benefits have been attributed to tea, especially green …

Potential role of natural antioxidant products in oncological diseases

P Marino, G Pepe, MG Basilicata, V Vestuto… - Antioxidants, 2023 - mdpi.com
Nutrition has a significant effect and a crucial role in disease prevention. Low consumption
of fruit and vegetables and a sedentary lifestyle are closely related with the onset and …

Nanodelivery of dietary polyphenols for therapeutic applications

M Rudrapal, AK Mishra, L Rani, KK Sarwa… - Molecules, 2022 - mdpi.com
Advancement in nanotechnology has unleashed the therapeutic potentials of dietary
polyphenols by enhancing bioavailability, improving biological half-life, and allowing site …

Cancer preventive activities of tea catechins

CS Yang, H Wang - Molecules, 2016 - mdpi.com
Catechins are widely occurring in our diet and beverages. The cancer-preventive activities
of catechins have been extensively studied. Of these,(−)-epigallocatechin-3-gallate (EGCG) …

Targeting NOX, INOS and COX‐2 in inflammatory cells: chemoprevention using food phytochemicals

A Murakami, H Ohigashi - International journal of cancer, 2007 - Wiley Online Library
Biological, biochemical and physical stimuli activate inflammatory leukocytes, such as
macrophages, resulting in induction and synthesis of proinflammatory proteins and …

Stability of tea polyphenol (−)-epigallocatechin-3-gallate and formation of dimers and epimers under common experimental conditions

S Sang, MJ Lee, Z Hou, CT Ho… - Journal of agricultural and …, 2005 - ACS Publications
(−)-Epigallocatechin-3-gallate (EGCG), the most abundant and biologically active compound
in tea, has been extensively studied for its activities related to disease prevention in animal …