The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …

The endoplasmic reticulum (ER) has recently emerged as a promising target for anticancer
agents. Cytotoxic compounds that target the ER often exhibit selectivity for cancer cells over …

The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for …

Seven rhenium (I) complexes of the general formula fac-[Re (CO) 3 (NN)(OH2)]+ where NN=
2, 2′-bipyridine (8), 4, 4′-dimethyl-2, 2′-bipyridine (9), 4, 4′-dimethoxy-2, 2′-bipyridine …

Translation is the most energy-consuming activity within cells. Due to metabolic demands
and high proliferation, cancer cells require elevated rates of protein synthesis, thus providing …

The amount of unfolded proteins is increased in cancer cells, leading to endoplasmic
reticulum (ER) stress. Therefore, cancer cells are sensitive to drugs capable of further …

The development of iridium complexes as potent anticancer agents has received increasing
attention in recent years. In this study, four cyclometalated Ir (III) complexes with good …

Known as highly efficient metallodrugs that have been clinically used to treat various types
of cancers, cisplatin and its analogues have attracted and inspired extensive interest in the …

The combination of chemotherapeutic and photodynamic activities in an iridium-based
molecular compound is less reported. Herein, two iridium complexes (IrC1 and IrC2) with β …

Great attention has been bestowed upon iridium (III) complexes as anticancer agents in
recent years, and a variety of them, in particular, are luminescent. The phosphorescence of …