The process of senescence (aging) is predominantly determined by the action of wild-type
genes. For most organisms, this does not reflect any adaptive function that senescence …

Between the 1930s and 50s, evolutionary biologists developed a successful theory of why
organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of …

In human populations, women consistently outlive men, which suggests profound biological
foundations for sex differences in survival. Quantifying whether such sex differences are also …

Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a
maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and …

Life-history traits or “fitness components”—such as age and size at maturity, fecundity and
fertility, age-specific rates of survival, and life span—are the major phenotypic determinants …

Abstract Lay Summary: An evolutionary mechanism of aging was hypothesized 60 years
ago to be the genetic trade-off between early life fitness and late life mortality. Genetic …

Aging animals display a broad range of progressive degenerative changes, and one of the
most fascinating is the decline of female reproductive function. In the model organism …

It is well known that women live longer than men. This gap is observed in most human
populations and can even reach 10–15 years. In addition, most of the known super …

Why and how we age are 2 intertwined questions that have fascinated scientists for many
decades. However, attempts to answer these questions remain compartmentalized …

At a recent symposium on aging biology, a debate was held as to whether or not we know
what biological aging is. Most of the participants were struck not only by the lack of …