Telomeres are nucleoprotein structures that cap the end of each chromosome arm and
function to maintain genome stability. The length of telomeres is known to shorten with each …

As a compartment border, the nuclear envelope (NE) needs to serve as both a protective
membrane shell for the genome and a versatile communication interface between the …

Defects in the architecture or integrity of the nuclear envelope are associated with a variety
of human diseases. Micronuclei, one common nuclear aberration, are an origin for …

Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

Micronuclei are small DNA-containing nuclear structures that are spatially isolated from the
main nucleus. They are frequently found in pathologies, including cancer. It was recently …

Eukaryotic cells store their chromosomes in a single nucleus. This is important to maintain
genomic integrity, as chromosomes packaged into separate nuclei (micronuclei) are prone …

Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …

Because of the association between aberrant nuclear structure and tumour grade, nuclear
morphology is an indispensible criterion in the current pathological assessment of cancer …

The nuclear lamins are type V intermediate filament proteins that are critically important for
the structural properties of the nucleus. In addition, they are involved in the regulation of …

Cell division in eukaryotes requires extensive architectural changes of the nuclear envelope
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …