Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

This comprehensive review surveys developments over the past decade in the field of
naphthalene diimides (NDIs). It explores their application toward: supramolecular chemistry; …

The integrin αvβ3 plays an important role in angiogenesis. It is expressed on tumoral
endothelial cells as well as on some tumor cells. RGD peptides are well-known to bind …

The photoisomerization of azobenzene has been known for almost 75 years but only
recently has this process been widely applied to biological systems. The central challenge of …

Nanoparticle-based materials, such as drug delivery vehicles and diagnostic probes,
currently under evaluation in oncology clinical trials are largely not tumor selective. To be …

Molecular imaging can allow the non-invasive assessment of biological and biochemical
processes in living subjects. Such technologies therefore have the potential to enhance our …

Advances in imaging are transforming our understanding of angiogenesis and the
evaluation of drugs that stimulate or inhibit angiogenesis in preclinical models and human …

Early diagnosis is essential for completely eradicating skin cancer and maximizing patients'
clinical benefits. Emerging optical imaging modalities such as reflectance confocal …

Inhibitors of αvβ3 and αvβ5 integrin have entered clinical trials as antiangiogenic agents for
cancer treatment but generally have been unsuccessful. Here we present in vivo evidence …

The development of miniaturized imaging equipment and reporter probes has improved our
ability to study animal models of disease, such as transgenic and knockout mice. These …