Abstract V (D) J recombination assembles antigen receptor genes from component gene
segments. We review findings that have shaped our current understanding of this …

Publisher Summary This chapter attempts an interdisciplinary perspective to consider that
that both molecular biologists and immunologists have learned about the V (D) J …

The ability to generate a diverse immune response depends on the somatic assembly of
genes that encode the antigen-binding portions of immunoglobulin molecules. In this article …

Two conserved DNA sequences serve as joining signals in the assembly of
immunoglobulins and T-cell receptors from V-,(D)-, and J-coding segments during lymphoid …

An understanding of the retroviral life cycle and the ability to manipulate the viral genome
has allowed the development of gene transfer vectors which utilize the efficient gene transfer …

The presence of autoantibodies is a defining feature of many autoimmune diseases. The
number of unique autoantibody clones is conceivably limited by immune tolerance …

Sequences encoding immunoglobulin variable domains are known to be assembled from
variable (V), diversity (D), and joining (J) segments by site-specific recombination. We …

A functional B cell antigen receptor is thought to regulate antibody gene rearrangement
either by stop** further rearrangement (exclusion) or by promoting additional …

FUNCTIONAL impairment and selective depletion of CD4+ T cells, the hallmark of AIDS, are
at least partly caused by human immunodeficiency virus (HIV-1) type 1 binding to the CD4 …

The minimum sequence requirements for antigen receptor V-(D)-J joining were studied by
constructing recombination-substrates containing synthetic recombination signals and …