Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments

R Ruze, T Liu, X Zou, J Song, Y Chen, R Xu… - Frontiers in …, 2023 - frontiersin.org
The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …

[HTML][HTML] Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

LE McCoubrey, A Favaron, A Awad, M Orlu… - Journal of Controlled …, 2023 - Elsevier
Colonic drug delivery can facilitate access to unique therapeutic targets and has the
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …

[HTML][HTML] Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity

I Leonardi, IH Gao, WY Lin, M Allen, XV Li, WD Fiers… - Cell, 2022 - cell.com
Fungal communities (the mycobiota) are an integral part of the gut microbiota, and the
disruption of their integrity contributes to local and gut-distal pathologies. Yet, the …

An integrated gene catalog and over 10,000 metagenome-assembled genomes from the gastrointestinal microbiome of ruminants

F **e, W **, H Si, Y Yuan, Y Tao, J Liu, X Wang… - Microbiome, 2021 - Springer
Background Gastrointestinal tract (GIT) microbiomes in ruminants play major roles in host
health and thus animal production. However, we lack an integrated understanding of …

Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target

K Wang, Z Zhang, J Hang, J Liu, F Guo, Y Ding, M Li… - Science, 2023 - science.org
A mechanistic understanding of how microbial proteins affect the host could yield deeper
insights into gut microbiota–host cross-talk. We developed an enzyme activity–screening …

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

LY Zhao, JX Mei, G Yu, L Lei, WH Zhang… - … and Targeted Therapy, 2023 - nature.com
In the past period, due to the rapid development of next-generation sequencing technology,
accumulating evidence has clarified the complex role of the human microbiota in the …

Mycotoxin and gut microbiota interactions

P Guerre - Toxins, 2020 - mdpi.com
The interactions between mycotoxins and gut microbiota were discovered early in animals
and explained part of the differences in susceptibility to mycotoxins among species. Isolation …

Macrophages in the gut: Masters in multitasking

M Delfini, N Stakenborg, MF Viola, G Boeckxstaens - Immunity, 2022 - cell.com
The gastrointestinal tract has the important task of absorbing nutrients, a complex process
that requires an intact barrier allowing the passage of nutrients but that simultaneously …

The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease

RM Chakaroun, LM Olsson, F Bäckhed - Nature Reviews Cardiology, 2023 - nature.com
Despite milestones in preventive measures and treatment, cardiovascular disease (CVD)
remains associated with a high burden of morbidity and mortality. The protracted nature of …

Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome

ACD Machado, SD Brown, A Lingaraju, V Sivaganesh… - Cell reports, 2022 - cell.com
Compositional oscillations of the gut microbiome are essential for normal peripheral
circadian rhythms, both of which are disrupted in diet-induced obesity (DIO). Although time …