Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments
R Ruze, T Liu, X Zou, J Song, Y Chen, R Xu… - Frontiers in …, 2023 - frontiersin.org
The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …
[HTML][HTML] Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics
Colonic drug delivery can facilitate access to unique therapeutic targets and has the
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …
potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to …
[HTML][HTML] Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity
Fungal communities (the mycobiota) are an integral part of the gut microbiota, and the
disruption of their integrity contributes to local and gut-distal pathologies. Yet, the …
disruption of their integrity contributes to local and gut-distal pathologies. Yet, the …
An integrated gene catalog and over 10,000 metagenome-assembled genomes from the gastrointestinal microbiome of ruminants
Background Gastrointestinal tract (GIT) microbiomes in ruminants play major roles in host
health and thus animal production. However, we lack an integrated understanding of …
health and thus animal production. However, we lack an integrated understanding of …
Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target
K Wang, Z Zhang, J Hang, J Liu, F Guo, Y Ding, M Li… - Science, 2023 - science.org
A mechanistic understanding of how microbial proteins affect the host could yield deeper
insights into gut microbiota–host cross-talk. We developed an enzyme activity–screening …
insights into gut microbiota–host cross-talk. We developed an enzyme activity–screening …
Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications
LY Zhao, JX Mei, G Yu, L Lei, WH Zhang… - … and Targeted Therapy, 2023 - nature.com
In the past period, due to the rapid development of next-generation sequencing technology,
accumulating evidence has clarified the complex role of the human microbiota in the …
accumulating evidence has clarified the complex role of the human microbiota in the …
Mycotoxin and gut microbiota interactions
P Guerre - Toxins, 2020 - mdpi.com
The interactions between mycotoxins and gut microbiota were discovered early in animals
and explained part of the differences in susceptibility to mycotoxins among species. Isolation …
and explained part of the differences in susceptibility to mycotoxins among species. Isolation …
Macrophages in the gut: Masters in multitasking
M Delfini, N Stakenborg, MF Viola, G Boeckxstaens - Immunity, 2022 - cell.com
The gastrointestinal tract has the important task of absorbing nutrients, a complex process
that requires an intact barrier allowing the passage of nutrients but that simultaneously …
that requires an intact barrier allowing the passage of nutrients but that simultaneously …
The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease
RM Chakaroun, LM Olsson, F Bäckhed - Nature Reviews Cardiology, 2023 - nature.com
Despite milestones in preventive measures and treatment, cardiovascular disease (CVD)
remains associated with a high burden of morbidity and mortality. The protracted nature of …
remains associated with a high burden of morbidity and mortality. The protracted nature of …
Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome
Compositional oscillations of the gut microbiome are essential for normal peripheral
circadian rhythms, both of which are disrupted in diet-induced obesity (DIO). Although time …
circadian rhythms, both of which are disrupted in diet-induced obesity (DIO). Although time …