The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …

Tumor microvasculature tends to be malformed, more permeable, and more tortuous than
vessels in healthy tissue, effects that have been largely attributed to up-regulated VEGF …

This protocol describes a simple but robust microfluidic assay combining three-dimensional
(3D) and two-dimensional (2D) cell culture. The microfluidic platform comprises hydrogel …

Angiogenesis, or the formation of new blood vessels from the preexisting vasculature, is a
key component in numerous physiologic and pathologic responses and has broad impact in …

Capillary morphogenesis is a complex cellular process that occurs in response to external
stimuli. A number of assays have been used to study critical regulators of the process, but …

Modeling the in vivo microenvironment typically involves placing cells in a three-
dimensional (3D) extracellular matrix (ECM) in physiologically relevant context with respect …

To investigate the anti-inflammatory and anti-angiogenic effects of mesenchymal stem cells
(MSC) in the chemically burned corneas, we mechanically removed the corneal epithelium …

Co-cultures of endothelial cells (EC) and mesenchymal stem cells (MSC) in three-
dimensional (3D) protein hydrogels can be used to recapitulate aspects of vasculogenesis …

Mesenchymal stem cells (MSCs) have great potential as a source of cells for cell-based
therapy because of their ability for self-renewal and differentiation into functional cells …