Mitochondria–endoplasmic reticulum (ER) contact sites (MERCS) function as transient
signaling platforms that regulate essential cellular functions. MERCS are enriched in specific …

Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP)(cGAMP)
synthase (cGAS) is a cytosolic DNA sensor that produces the secondary messenger cGAMP …

Carling et al. report that late-onset Alzheimer's disease (LOAD) risk alleles drive cellular
senescence, a hallmark of aging, in a tau-and sex-dependent manner. Mechanistic insights …

Cellular senescence is a cell state triggered by programmed physiological processes or
cellular stress responses. Stress-induced senescent cells often acquire pathogenic traits …

Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a key component of the evolutionary
conserved immune response pathway, acting upstream stimulator of interferon genes …

INTRODUCTION Altered immune signatures are emerging as a central theme in
neurodegenerative disease, yet little is known about immune responses in early‐onset …

Recent advances in transcriptomics research have uncovered heightened interferon (IFN)
responses in neurodegenerative diseases including Alzheimer's disease, primary …

Neurodegenerative diseases (NDs) are a group of neurological disorders characterized by
the progressive loss of selected neurons. Alzheimer's disease (AD) and Parkinson's disease …

Type I interferons are a class of potent and tightly regulated cytokines important for antiviral
and anti-tumoural innate and adaptive immunity. Dysregulated production can have serious …