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Therapeutic targeting of tumour myeloid cells
Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …
Control of tumor-associated macrophage responses by nutrient acquisition and metabolism
Metazoan tissue specification is associated with integration of macrophage lineage cells in
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …
sub-tissular niches to promote tissue development and homeostasis. Oncogenic …
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer
Natural killer (NK) cells are commonly reduced in human tumors, enabling many to evade
surveillance. Here, we sought to identify cues that alter NK cell activity in tumors. We found …
surveillance. Here, we sought to identify cues that alter NK cell activity in tumors. We found …
Metabolic regulation of the immune system in health and diseases: mechanisms and interventions
T Hu, CH Liu, M Lei, Q Zeng, L Li, H Tang… - Signal Transduction and …, 2024 - nature.com
Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other
metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic …
metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic …
The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized …
In recent years, advancements in single-cell and spatial transcriptomics, which are highly
regarded developments in the current era, particularly the emerging integration of single-cell …
regarded developments in the current era, particularly the emerging integration of single-cell …
Nonresolving inflammation redux
Nonresolving inflammation contributes to many diseases, including COVID-19 in its fatal and
long forms. Our understanding of inflammation is rapidly evolving. Like the immune system …
long forms. Our understanding of inflammation is rapidly evolving. Like the immune system …
Lipid-associated macrophages between aggravation and alleviation of metabolic diseases
Lipid-associated macrophages (LAMs) are phagocytic cells with lipid-handling capacity
identified in various metabolic derangements. During disease development, they locate to …
identified in various metabolic derangements. During disease development, they locate to …
Targeting macrophages: a novel treatment strategy in solid tumors
M Liu, L Liu, Y Song, W Li, L Xu - Journal of translational medicine, 2022 - Springer
In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) are the most
abundant immune cells, which act as a key regulator in tumorigenesis and progression …
abundant immune cells, which act as a key regulator in tumorigenesis and progression …
SPP1 represents a therapeutic target that promotes the progression of oesophageal squamous cell carcinoma by driving M2 macrophage infiltration
Abstract Background Tumour-associated macrophages (TAMs) are an important component
of the tumour microenvironment (TME). However, the crosstalk between oesophageal …
of the tumour microenvironment (TME). However, the crosstalk between oesophageal …
Lipid droplet accumulation mediates macrophage survival and Treg recruitment via the CCL20/CCR6 axis in human hepatocellular carcinoma
Y Wang, W Chen, S Qiao, H Zou, X Yu… - Cellular & Molecular …, 2024 - nature.com
Metabolic changes play a crucial role in determining the status and function of
macrophages, but how lipid reprogramming in macrophages contributes to tumor …
macrophages, but how lipid reprogramming in macrophages contributes to tumor …