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More than a metabolic enzyme: MTHFD2 as a novel target for anticancer therapy?
Z Zhu, GKK Leung - Frontiers in oncology, 2020 - frontiersin.org
The bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a
mitochondrial one-carbon folate metabolic enzyme whose role in cancer was not known …
mitochondrial one-carbon folate metabolic enzyme whose role in cancer was not known …
Enterotypical Prevotella and three novel bacterial biomarkers in preoperative stool predict the clinical outcome of colorectal cancer
Background A significant proportion of colorectal cancer (CRC) patients suffer from early
recurrence and progression after surgical treatment. Although the gut microbiota is …
recurrence and progression after surgical treatment. Although the gut microbiota is …
[HTML][HTML] The Impact of Developmental and Metabolic Cues on Cytoophidium Formation
The cytoophidium, composed mainly of CTP synthase (CTPS), is a newly discovered
dynamic filamentous structure in various organisms such as archaea, bacteria, and humans …
dynamic filamentous structure in various organisms such as archaea, bacteria, and humans …
Structural basis for ligand binding modes of CTP synthase
Cytidine triphosphate synthase (CTPS), which comprises an ammonia ligase domain and a
glutamine amidotransferase domain, catalyzes the final step of de novo CTP biosynthesis …
glutamine amidotransferase domain, catalyzes the final step of de novo CTP biosynthesis …
Filamentation modulates allosteric regulation of PRPS
Phosphoribosyl pyrophosphate (PRPP) is a key intermediate in the biosynthesis of purine
and pyrimidine nucleotides, histidine, tryptophan, and cofactors NAD and NADP. Abnormal …
and pyrimidine nucleotides, histidine, tryptophan, and cofactors NAD and NADP. Abnormal …
Light-sensitive phosphorylation regulates retinal IMPDH1 activity and filament assembly
Inosine monophosphate dehydrogenase (IMPDH) is the rate-limiting enzyme in guanosine
triphosphate (GTP) synthesis and assembles into filaments in cells, which desensitizes the …
triphosphate (GTP) synthesis and assembles into filaments in cells, which desensitizes the …
Freedom of assembly: metabolic enzymes come together
Many different enzymes in intermediate metabolism dynamically assemble filamentous
polymers in cells, often in response to changes in physiological conditions. Most of the …
polymers in cells, often in response to changes in physiological conditions. Most of the …
Forming cytoophidia prolongs the half-life of CTP synthase
Z Sun, JL Liu - Cell discovery, 2019 - nature.com
Dear Editor, Intracellular compartmentation of biological processes is fundamental for a cell
to function. One method is to form membrane-bound organelles, such as the mitochondria …
to function. One method is to form membrane-bound organelles, such as the mitochondria …
Down‐regulation of MTHFD2 inhibits NSCLC progression by suppressing cycle‐related genes
Abstract Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a bifunctional enzyme
located in the mitochondria. It has been reported to be overexpressed in several …
located in the mitochondria. It has been reported to be overexpressed in several …
Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation
The cytoophidium is a unique type of membraneless compartment comprising of filamentous
protein polymers. Inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate …
protein polymers. Inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate …