Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula

L Zhao, H Zhang, N Li, J Chen, H Xu, Y Wang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Network pharmacology is a new discipline based on
systems biology theory, biological system network analysis, and multi-target drug molecule …

Integration strategy of network pharmacology in Traditional Chinese Medicine: a narrative review

WU Jiashuo, F ZHANG… - Journal of …, 2022 - pmc.ncbi.nlm.nih.gov
Traditional Chinese Medicine (TCM) has been extensively used as a mainstay for treating
various pathologies. Combing the pharmacology and systems biology approaches, the …

A deep learning method for predicting metabolite–disease associations via graph neural network

F Sun, J Sun, Q Zhao - Briefings in bioinformatics, 2022 - academic.oup.com
Metabolism is the process by which an organism continuously replaces old substances with
new substances. It plays an important role in maintaining human life, body growth and …

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

R Karlsson Linnér, TT Mallard, PB Barr… - Nature …, 2021 - nature.com
Behaviors and disorders related to self-regulation, such as substance use, antisocial
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …

Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system

P Zhang, JH Catterson, S Grönke, L Partridge - Nature Aging, 2024 - nature.com
Suppression of target of rapamycin complex 1 (TORC1) by rapamycin ameliorates aging in
diverse species. S6 kinase (S6K) is an essential mediator, but the mechanisms involved are …

Network pharmacology databases for traditional Chinese medicine: review and assessment

R Zhang, X Zhu, H Bai, K Ning - Frontiers in pharmacology, 2019 - frontiersin.org
The research field of systems biology has greatly advanced and, as a result, the concept of
network pharmacology has been developed. This advancement, in turn, has shifted the …

Review of drug repositioning approaches and resources

H Xue, J Li, H **e, Y Wang - International journal of biological …, 2018 - pmc.ncbi.nlm.nih.gov
Drug discovery is a time-consuming, high-investment, and high-risk process in traditional
drug development. Drug repositioning has become a popular strategy in recent years …

OmicsNet 2.0: a web-based platform for multi-omics integration and network visual analytics

G Zhou, Z Pang, Y Lu, J Ewald, J **a - Nucleic acids research, 2022 - academic.oup.com
Researchers are increasingly seeking to interpret molecular data within a multi-omics
context to gain a more comprehensive picture of their study system. OmicsNet (www …

Network propagation: a universal amplifier of genetic associations

L Cowen, T Ideker, BJ Raphael, R Sharan - Nature Reviews Genetics, 2017 - nature.com
Biological networks are powerful resources for the discovery of genes and genetic modules
that drive disease. Fundamental to network analysis is the concept that genes underlying the …

MDHGI: matrix decomposition and heterogeneous graph inference for miRNA-disease association prediction

X Chen, J Yin, J Qu, L Huang - PLoS computational biology, 2018 - journals.plos.org
Recently, a growing number of biological research and scientific experiments have
demonstrated that microRNA (miRNA) affects the development of human complex diseases …